Results 221 to 230 of about 2,931,165 (316)

How will we prepare for an uncertain future? The value of open data and code for unborn generations facing climate change. [PDF]

Proc Biol Sci
Gomes DGE.
europepmc   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Utilization and regional disparities of radiotherapy in cancer treatment in Japan: a longitudinal study using NDB open data. [PDF]

J Radiat Res
Takeda K, Umezawa R, Yamamoto T, Takahashi N, Onishi H, Jingu K.   +5 more
europepmc   +1 more source

Open XML architecture for chemical data

, 2005
Peter Suber
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

The challenges of open data sharing for qualitative researchers. [PDF]

J Health Psychol
Lamb D, Russell A, Morant N, Stevenson F.   +3 more
europepmc   +1 more source

The Lung Tissue Research Consortium: An extensive open database containing histological, clinical, and radiological data to study chronic lung disease

, 2006
Brian J. Bartholmai, Ronald A. Karwoski, Vanessa A. Zavaletta, Richard A. Robb, David R. Holmes   +4 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

MetaboLights: open data repository for metabolomics. [PDF]

Nucleic Acids Res
Yurekten O, Payne T, Tejera N, Amaladoss FX, Martin C, Williams M, O'Donovan C.   +6 more
europepmc   +1 more source

Data-driven type checking in open domain question answering

, 2006
Stefan Schlobach, David Ahn, Maarten de Rijke, Valentin Jijkoun   +3 more
openalex   +1 more source