Results 71 to 80 of about 2,931,165 (316)

Long-Term Road Traffic Noise, Air Pollution, and Cardiovascular Disease AIRCARD

JACC: Advances
Background: Air pollution and road traffic noise are major environmental stressors associated with cardiovascular disease (CVD). Although their independent effects are well-documented, few studies have concurrently evaluated their relative contributions ...
Stephan P. Mayntz, MD, MPH, PhD, Roda A. Mohamed, MD, PhD, Anna Mejldal, PhD, Jens-Jakob K. Møller, PhD, Jes S. Lindholt, MD, DMSci, Axel CP. Diederichsen, MD, PhD, Lise M. Frohn, PhD, Jørgen Brandt, PhD, Matthias Ketzel, PhD, Jibran Khan, PhD, Jess Lambrechtsen, MD, PhD   +10 more
doaj   +1 more source

open science open data open source

, 2017
Making research findings available free of charge for all readers has been a major challenge identified by the European Commission. Several initiatives have been made to facilitate scientific data to the community. But has science progresses, the volume of data and platforms where information can be found also increases.
Vos, Rutger A., Fernandes, Pedro L.
openaire   +3 more sources

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Pushing the Scalability of RDF Engines on IoT Edge Devices

Sensors, 2020
Semantic interoperability for the Internet of Things (IoT) is enabled by standards and technologies from the Semantic Web. As recent research suggests a move towards decentralised IoT architectures, we have investigated the scalability and robustness of ...
Anh Le-Tuan, Conor Hayes , Manfred Hauswirth, Danh Le-Phuoc   +3 more
doaj   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Open data and open research

, 2019
Slides from invited panel discussion discussing the role of libraries in supporting research data management and reproducibility as part of furthering open research and open access. Panel description: What is the collective meaning for openness to librarians and what are its impacts to our profession?
openaire   +1 more source

Open Data Chatbot

, 2019
Recently, chatbots received an increased attention from industry and diverse research communities as a dialogue-based interface providing advanced human-computer interactions. On the other hand, Open Data continues to be an important trend and a potential enabler for government transparency and citizen participation.
Keyner, Sophia, Savenkov, Vadim, Vakulenko, Svitlana   +2 more
openaire   +4 more sources

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

FEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source