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Evaluation of Psychotropic Drugs with a Modified Open Field Test
Pharmacology, 2008The open field test used to study the behavioral alterations induced by psychotropic drugs is based mainly in the defecation, ambulation, rearing and grooming scores presented by animals subjected to the test. Because of the criticisms raised against the defecation score as a measure of the central effects of drugs, in the present experiment a ...
Cunha, J. M., Masur, J.
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Reliability of Various Measures Obtained in Open-Field Test
Psychological Reports, 19786 open-field measures, defecation, ambulation, urination, rearing, crossing, and freezing, were obtained. Subjects were tested twice. The first test was conducted when subjects were 105 days old and the second when they were 224 days old, that is, 4 mo. later.
M, Goma, A, Tobeña
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Factor analysis of rat behavior in an open field test
Neuroscience and Behavioral Physiology, 19891. The main portion (60%) of the variance of the behavior of Wistar rats in the open field test can be due to the effect of only three principal factors (components). 2. An analysis of the behavioral structure of these components showed that they can be designated as “exploration” (first component), “fear” (second), and “shifted activity”
A L, Markel +2 more
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Open Field and Water Wading as Tests of Emotionality in Rats
Psychological Reports, 197820 male and 20 female Wistar rats were assessed for open-field defecation and ambulation and for water wading defecation. Defecation in the two places was not correlated. While there was a significant inverse relationship between ambulation and defecation in the open field, ambulation in the open field and defecation while water wading were not related.
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A technique for monitoring the heart rate of rats in the open field test
Biological Psychology, 1973Abstract This report describes an inexpensive system for monitoring heart rate (HR) in rats during open field testing and related experimental situations, where a high level of locomotor activity is likely.
A, Jolley, R, Thomas
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“Anxiolytic” action of diazepam and abecarnil in a modified open field test
Pharmacology Biochemistry and Behavior, 1996The effects of acutely administered diazepam and the beta-carboline abecarnil were examined in two animal models of anxiety in rats, and for their effects on food intake and locomotor activity. In the elevated x-maze diazepam (0.6-2.5 mg/kg) and abecarnil (0.03-0.3 mg/kg) induced anxiolytic-like effects.
A, Rex, D N, Stephens, H, Fink
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Automated gait analysis in the open-field test for laboratory mice
Behavior Research Methods, 2009In this article, an automated and accurate mouse observation method, based on a conventional test for motor function evaluation, is outlined. The proposed measurement technique was integrated in a regular open-field test, where the trajectory and locomotion of a free-moving mouse were measured simultaneously. The system setup consisted of a transparent
Toon, Leroy +4 more
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Open-Field Test for Rats: Correlational Analysis
Psychological Reports, 198296 male rats were tested in open field in dim-light condition or bright-light condition for 3 min. per day for 5 days. The validity of 7 open-field test measures was assessed on the basis of the concept which was defined operationally using the test situation as the external criterion. Ambulation in the first 1 min. and rearing showed not only validity
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Anxiolytic potential of a microgram dose of chlordiazepoxide in the open-field test
European Journal of Pharmacology, 1990Diazepam, when administered in very low doses (100 micrograms/kg), can induce a specific inhibition of coarse and ambulation activities in the rat, suggesting a novel mechanism of action occurring in the microgram dose range. This study fails to reproduce the same effects with chlordiazepoxide.
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The open-field test: A critical review.
Psychological Bulletin, 1976R N, Walsh, R A, Cummins
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