Results 61 to 70 of about 16,607,492 (282)

PREDICTING SEVERITY AND VISUAL OUTCOMES OF EYE TRAUMA FOLLOWING TREATEMENT, USING OCULAR TRAUMA SCALE

open access: yesPakistan Armed Forces Medical Journal, 2020
Objective: To predict the severity and visual outcomes following treatment in patients sustaining eye trauma using ocular trauma scale. Study Design: Retrospective case series.
Teyyeb Azeem Janjua   +3 more
doaj   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Remarkable visual recovery after severe open globe injury

open access: yes, 2018
Purpose To describe a case of remarkable visual recovery after severe open globe injury. Observations We present a case of a 70-year-old man with an open globe injury with no light perception vision before and after primary repair of his ruptured globe ...
Eliott, Dean   +2 more
core   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

Demographic Characteristics and Clinical Outcome of Work-related Open Globe Injuries in the Most Industrialised Region of Turkey

open access: yes, 2017
Objectives: To evaluate demographic characteristics and clinical outcomes of work-related open globe injuries in the most industrialized region of Turkey.
Mediha Tok Çevik   +3 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

An unusual cause of globe rupture in a child and its management

open access: yesTNOA Journal of Ophthalmic Science and Research, 2018
Globe rupture in children usually occurs from injury with sharp objects. Our patient had a pungai (Indian beech tree) seed thrown at his right eye and presented with ruptured globe.
Anand Ravi Kumar   +2 more
doaj   +1 more source

PATTERN OF OCULAR TRAUMA IN BENGAHZI EYE HOSPITAL BENGAHZIS – LIBYA

open access: yesLibyan International Medical University Journal, 2017
Background   This  study  was  conducted  to  determine  the  pattern  of ocular trauma  in  Benghazi- Libya . Methods   All  cases  of  ocular  trauma  admitted  to  Benghazi  eye hospital  from January  2011  to  August  2012  were  retrospectively ...
mariam m gebril
doaj  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

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