Results 121 to 130 of about 841,980 (298)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

[Creating Impact from Open Government Data: What Are the Keys to Success?] [PDF]

HMD Prax Wirtsch Inform, 2021
Neumann O, Mettler T.
europepmc   +1 more source

What’s in a name? A comparison of ‘open government’ definitions across seven Open Government Partnership members

, 2014
No longer restricted to access to information laws and accountability measures, “open government” is now associated with a broad range of goals and functions, including public participation, open data, the improvement of public services and government ...
Clarke, Amanda, Francoli, Mary
core   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Open government in Uruguay: Strengthening dialogue to make up for institutional challenges

, 2015
In Uruguay, innovative practices of consultation and dialogue between government and civil society have enlarged the scope of open government reforms.
Guillán, Aránzazu
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Perception and Reuse of Open Data in the Spanish University Teaching and Research Community

Data
Introduction. Open Government is a form of public policy based on the pillars of collaboration and citizen participation, transparency and the right of access to public information. With the help of information and communication technologies, governments
Christian Vidal-Cabo, Enrique Alfonso Sánchez-Pérez, Antonia Ferrer-Sapena   +2 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

TWC LOGD: A Portal for Linked Open Government Data Ecosystems

, 2011
pages 1 - 11International open government initiatives are releasing an increasing volume of raw government datasets directly to citizens via the Web. The transparency resulting from these releases creates new application opportunities but also imposes ...
Flores, Johanna, Williams, Gregory, Hendler, James A., Michaelis, James, Li, Xian, Erickson, John S., Graves, Alvaro, Zheng, Jin, DiFranzo, Dominic, Ding, Li, McGuinness, Deborah L., Lebo, Tim   +11 more
core  

OGD2011 – Requirements Analysis for an Open Data Strategy (in Austria)

, 2011
Part 2: eEnvironment and Cross-Border Services in Digital Agenda for EuropeInternational audienceThe OGD2011 project launches the 1st Open Government Data Conference Austria and brings together international and national experts in the area of Open ...
Kaltenböck, Martin, Martin Kaltenböck
core   +1 more source