Results 131 to 140 of about 4,169,410 (295)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Evaluación de los portales de transparencia en las comunidades autónomas españolas
Revista Vasca de Administración PúblicaThe piece looks at the transparency portals of Spain¿s autonomous communities and assesses their maturity using an index that covers open government, regulatory compliance, and best practices for reusing public information.
Lander Jauregi-Maza
doaj +1 more source
The Composition of Government Spending and the Real Exchange Rate [PDF]
We show that the composition of government spending influences the long-run behaviour of the real exchange rate. We develop a two-sector small open economy model in which an increase in government consumption is associated with real appreciation, while ...
Vahagn Galstyan and Philip R. Lane
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Bestuurlijke kwetsbaarheid in het overheidsinformatierecht
Tilburg Law ReviewHet recht op toegang tot overheidsinformatie is een fundamenteel recht voor burgers: zonder informatie is het onmogelijk om de overheid te controleren.
Shirley Kempeneer, Johan Wolswinkel
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
How dangerous is your life? Personalising Government open crime data [PDF]
, 2012 This paper discusses the use of Government Open Data and how public services based on this data can and should encourage data personalisation. We present our case study Fearsquare, an application that allows people to interact with public UK crime ...
Garbett, Andrew +4 more
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Revista Vasca de Administración Pública, 2014 Public administrations require to carry out a constant modernising process in order to adapt itself to the changing needs of citizenship. The model of traditional representative democracy is not sufficient in the present circumstances, where citizens ...
Silvia Carmona Garias
doaj +1 more source
Scientific literacy through co-inquiry based on non-formal and informal learning [PDF]
, 2014 This paper presents a collaborative research on scientific citizenship developed by the Open University UK (OU) through the weSPOT project for inquiry based learning and the Universidade do Estado da Bahia (UNEB) responsible for coordinating the ...
Okada, Alexandra +2 more
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