Results 71 to 80 of about 3,992,544 (296)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Do Transparency and Open Data Walk Together? An Analysis of Initiatives in Five Brazilian Capital
Medijske Studije, 2016 In the last few years, Brazilian municipal governments have launched their open data web portals. These initiatives have been taking place as part of the implementation of the Transparency Act, which sets forth deadlines and punishments concerning the ...
Ana Carolina Araújo +2 more
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Maintaining a Critical yet Hopeful Worldview in Achieving Sustainable Development
The Journal of Indonesia Sustainable Development Planning, 2023 Andrieta Rafaela Arifin
doaj +1 more source
Sometimes the Silence Can Be like the Thunder: Access to Pharmaceutical Data at the FDA [PDF]
, 2006 Those committed to the free exchange of scientific information have long complained about various restrictions on access to the FDA\u27s pharmaceutical data and the resultant restrictions on open discourse.
Ankelhed, Daniel +2 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2014 Aim of investigation. To estimate effect of biofeedback-therapy (BFT) on clinical symptoms, quality of life, sensorimotor function of anorectal area at irritable bowel syndrome (IBS) with refractory constipation (IBS-C).Material and methods.
O. V. Krapivnaya
doaj
Editorial: Open Source in Government [PDF]
Technology Innovation Management Review, 2009 Last summer, the Center for Strategic and International Studies published the sixth update to their Open Source Policy survey. The survey "tracks governmental policies on the use of open source software as reported in the press or other media." The ...
Dru Lavigne, James Bowen
doaj
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Historical Evolution and Prevention of Westophobia in Muslim Societies
Journal of Islamic Thought and Civilization, 2023 Confrontational religious, economic, and political issues have created an intolerant environment globally. The clashes between the worlds have not only disturbed and manipulated both civilizations but also illustrated the faults on the global world ...
Muhammad Riaz Mahmood +2 more
doaj