Results 81 to 90 of about 4,169,410 (295)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Effect of biofeedback – therapy on clinical semiology, quality of life and sensorimotor function of anorectal area at irritable bowel syndrome with refractory constipation

open access: yesРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии, 2014
Aim of investigation. To estimate effect of biofeedback-therapy (BFT) on clinical symptoms, quality of life, sensorimotor function of anorectal area at irritable bowel syndrome (IBS) with refractory constipation (IBS-C).Material and methods.
O. V. Krapivnaya
doaj  

Editorial: Open Source in Government [PDF]

open access: yesTechnology Innovation Management Review, 2009
Last summer, the Center for Strategic and International Studies published the sixth update to their Open Source Policy survey. The survey "tracks governmental policies on the use of open source software as reported in the press or other media." The ...
Dru Lavigne, James Bowen
doaj  

ICT, open government and civil society [PDF]

open access: yes
This paper explores the rise of ICTs as instruments of government reform and the implication of their use from the vantage point of the relations between democratic governance, the aims of Buen Vivir, and the role of civil society. We discuss some of the
Daniel Araya   +3 more
core  

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Civic Hackathons: New Terrain for Local Government-Citizen Interaction?

open access: yesUrban Planning, 2016
As more and more governments share open data, tech developers respond by creating apps using these data to generate content or provide services that citizens may find useful. More recently, there is an increase in popularity of the civic hackathon. These
Pamela J. Robinson, Peter A. Johnson
doaj   +1 more source

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