Results 71 to 80 of about 4,169,410 (295)

The "coming day" of digital government in the United States: a strategy for artificial intelligence

Aspekti Publìčnogo Upravlìnnâ, 2020
The US Department of Defense Artificial Intelligence Strategy (2018) as a pilot project of promising e-modernization of the public sector of this country is analyzed, its place among other initiatives on digitalization of public administration of the ...
Oleksii Onufriienko
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Open Government in Spain: An Introspective Analysis

Administrative Sciences
In recent years, there has been an increasing amount of research analyzing open government initiatives that enable access to the information held by public bodies, promoting accountability and the fight against corruption.
Ricardo Curto-Rodríguez, Rafael Marcos-Sánchez, Daniel Ferrández   +2 more
doaj   +1 more source

Do Transparency and Open Data Walk Together? An Analysis of Initiatives in Five Brazilian Capital

Medijske Studije, 2016
In the last few years, Brazilian municipal governments have launched their open data web portals. These initiatives have been taking place as part of the implementation of the Transparency Act, which sets forth deadlines and punishments concerning the ...
Ana Carolina Araújo, Lucas Reis, Rafael Cardoso Sampaio   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Maintaining a Critical yet Hopeful Worldview in Achieving Sustainable Development

The Journal of Indonesia Sustainable Development Planning, 2023
Andrieta Rafaela Arifin
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Working Paper: Open Government Data [PDF]

, 2010
In diesem Working Paper sollen wesentliche Erkenntnisse und Forderungen aus der - bisher vor allem englischsprachigen - Diskussion über die webgerechte Freigabe öffentlicher Daten zusammengefaßt werden.
Heller, Lambert, Hauschke, Christian
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Delivering on Open Government: The Obama Administration's Unfinished Legacy [PDF]

, 2013
This report examines progress made during President Obama's first term toward open government goals outlined in a comprehensive set of recommendations that the open government community issued in November 2008, titled Moving Toward a 21st Century Right ...
Gavin Baker, Sean Moulton
core