Results 61 to 70 of about 2,886,776 (296)
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Dimensional enrichment of statistical linked open data [PDF]
, 2016 On-Line Analytical Processing (OLAP) is a data analysis technique typically used for local and well-prepared data. However, initiatives like Open Data and Open Government bring new and publicly available data on the web that are to be analyzed in the ...
Bach Pedersen, Torben +5 more
core +2 more sources
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Open geospatial data: A comparison of data cultures in local government
IASSIST Quarterly, 2022 Public geospatial data (geodata) is created at all levels of government, including federal, state, and local (county and municipal). Local governments, in particular, are critical sources of geodata because they produce foundational datasets, such as ...
Karen Majewicz +2 more
doaj +1 more source
U.S. SDG Data Revolution Roadmap [PDF]
, 2017 One year after adopting the SDGs, in an addendum to its Open Government National Action Plan, the U.S. Government committed to develop an SDG Data Revolution Roadmap that "charts the future course of efforts to fill data gaps and build capacity to use ...
Aditya Agrawal +4 more
core
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Embedding open data practice: Developing indicators on the institutionalisation of open data practice in two African governments [PDF]
, 2015 Final research report of the “Embedding open data practice: Developing indicators on the institutionalisation of open data practice in two African governments” project, which formed part of the World Wide Web Foundation’s "Emerging Impacts of Open Data ...
van Schalkwyk, Francois +2 more
core +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Open government data infrastructures [PDF]
, 2021 Πληθώρα κυβερνήσεων και κυβερνητικών οργανισμών σε όλο τον κόσμο πραγματοποιούν μεγάλες επενδύσεις για την ανάπτυξη πληροφοριακών συστημάτων που βοηθούν στη δημοσίευση των δεδομένων που έχουν στην κατοχή τους ώστε να τα καταστίσουν κοινώς προσβάσιμα, προκειμένου να χρησιμοποιούνται για επιστημονικούς, εμπορικούς και πολιτικούς σκοπούς.
openaire +1 more source