Results 71 to 80 of about 39,328,094 (290)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Exploring the Impact of Adopting Open Data in the UK Government
, 2012 A new kind of activity – fuelled by the capabilities that not only modern Web technologies offer, but also as a change in social practices and expectations – has recently become the centre of much attention and discussion; it involves the curation and ...
Ramine Tinati +7 more
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Licensing Open Government Data
CoRRThis article focuses on the legal issues associated with open government data licenses. This study compares current open data licenses and argues that licensing terms reflect policy considerations, which are quite different from those contemplated in business transactions or shared in typical commons communities. This article investigates the ambiguous
openaire +2 more sources
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 2004 Title from screen 1, right panel (viewed Oct. 8, 2004).; "Auditor of State, Betty Montgomery."; Electronic text (pdf, 2 p.).; Harvested from the web on 10/8 ...
Ohio. Open Government Unit
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Open Data for Development : building an inclusive data revolution [PDF]
, 2016 Open Data for Development (OD4D) focuses on building the supply of quality open data, and improving its use by leaders in government, civil society, the media and business to further public interest and improve peoples’ lives.
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Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
, 2020 Open data and its effects on society are always woven into infrastructural legacies, social relations, and the political economy. This raises questions about how our understanding and engagement with open data shifts when we focus on its situated use. To
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