Results 91 to 100 of about 609,082 (292)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Management Analysis of Green Open Spaces in the Urban Area of Kalabahi

Loka: Journal Of Environmental Sciences
Purpose - The existence of green open spaces in the urban area of Kalabahi still requires the availability of land to achieve the target of at least 20% according to the mandate of Law Number 26 of 2007 concerning Spatial Planning and Regulation of the Minister of Home Affairs of the Republic of Indonesia Number 1 of 2007 concerning Arrangement of ...
Suhirman PANARA, Nursalam NURSALAM, Wenseslaus GAMPUR   +2 more
openaire   +1 more source

Green open spaces: climate mitigation of climate change in Indonesia

Introduction: The provision of microclimate for young people is an important prerequisite for outdoor thermal comfort in urban communities. The microclimate consists of four elements: air temperature, humidity, wind speed and solar radiation.
Agus, Fadilatur Rahmi, Ismail, Yunita
core   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Post-Earthquake Urban Planning in Türkiye: Evaluating Disaster Refuge Systems in Hatay and Istanbul

Journal of Architectural Sciences and Applications
Countries prone to significant earthquakes often develop disaster refuge and relief urban park systems to enhance urban open green spaces, which serve as temporary shelters for evacuation after seismic events.
Büşra Nur Gök, Gizem Dinç
doaj   +1 more source

Externalities Imposed on Residential Properties in Highly Urbanized Areas

, 2008
In highly industrialized areas open spaces such as farmland and nature are under pressure since urban areas are expanding at their expense. Because of the high opportunity costs of development in urban areas, a high price has to be paid for the ...
Cotteleer, G., Peerlings, J.H.M.
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Urban Spatial Naturalness Degree in the Planning of Ultra-High-Density Cities: The Case of Urban Green Open Spaces in Macau

Buildings
This study deeply examines the livable environment in high-density cities like Macau, focusing on urban green spaces. The study introduces the “urban spatial naturalness degree” indicator, exploring its application with urban population growth and green ...
Jitai Li, Fan Lin, Hongcan Cui, Shuai Yang, Yile Chen   +4 more
doaj   +1 more source

Aplikasi Penginderaan Jauh untuk Analisis Pengaruh Ruang Terbuka Hijau Terhadap Iklim Mikro di Kawasan Perkotaan Klaten

Majalah Geografi Indonesia, 2016
ABSTRAK Keberadaan RTH Hijau mulai tergusur oleh adanya pembangunan bangunan-bangunan baru di kawasan perkotaan. Salah satu fungsi dari RTH adalah sebagai pengatur dan penyeimbang iklim mikro. Citra ALOS Pan-Sharpened digunakan untuk interpretasi RTH dan
Eni Susanti, Iswari Nur Hidayati
doaj   +1 more source

Investigation Open and Green Areas Existence in The Boundaries of Protected Area of Edirne City

, 2015
The need of housing has raised within the increase of population and cities have development in unplanned way during the urbanization process. Being one of significant requirement of people, the importance of open and green spaces have increased during ...
Korkut, A. B., Aytin, B. Karakaya
core