Results 121 to 130 of about 22,030,632 (238)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

THE CONCEPT OF GREEN HOME IN HOUSING AREAS (FUTURE OPPORTUNITY AND CHALLENGE) [PDF]

, 2008
The concept of green home is a part of green architecture having the objective of harmonizing the inhabitants and the environment. In the context of real estate housing areas, various housing products having natural themes, such as, green city, green ...
Purwanto, Edi
core   +1 more source

Evaluation Open and Green Areas of Kayseri Urban Complex with a System Approach

Selçuk Üniversitesi Mühendislik, Bilim ve Teknoloji Dergisi, 2005
In urban environments green areas play an important part in forming good qualityenvironments with their ecological, economical, physical, social and aesthetic functions. Open and greenarea systems contribute the formation of urban communities by creating more livable environments. Inthis reseearch open and green areas have been searched in the frame of
KURTASLAN, Banu Öztürk, YAZGAN, Murat E.   +1 more
openaire   +1 more source

Open Green Area Strategies and Action Planning in Resilient Coastal Cities

Black Sea Journal of Engineering and Science
Cities, as complex entities composed of interdependent and multi-layered systems, are inherently vulnerable to both natural disasters and human-induced threats. Nevertheless, they are not only spaces exposed to adverse impacts but also strategic hubs for infrastructure, sustainability, technology, and investment.
Merve Sipahi, Şevval Bozkurt
openaire   +1 more source

Healthy Living Harlem: green mapping for eco-justice

, 2010
A map of the Harlem neighbourhood in New York City, NY showcasing green resources and landmarks as well as problem areas such as abandoned and contaminated ...
Faith Leaders for Environmental Justice, Center for International Earth Science Information Network   +1 more
core  

Green Roof Potential in Arab Cities [PDF]

, 2014
Urban green roofs have long been promoted as an easy and effective strategy for beautifying the built environment and increasing investment opportunity.
Attia, Shady
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A study about relationship between urban pattern and open green areas in Karşıyaka district

, 2003
Bu çalışma, açık-yeşil alanlar temelinde, yaşanabilir kent dokusu modeli için bir adım oluşturma amacını hedeflemektedir. Böylece, açık-yeşil alan standartları, gelişmiş ülkeler düzeyinde ele alınarak, yaşanabilir kent olgusu ilişkileri çerçevesinde ...
Erdem, Ümit, Yiğiter, Sibel
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source