Results 91 to 100 of about 21,603,813 (294)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Externalities Imposed on Residential Properties in Highly Urbanized Areas [PDF]

, 2008
In highly industrialized areas open spaces such as farmland and nature are under pressure since urban areas are expanding at their expense. Because of the high opportunity costs of development in urban areas, a high price has to be paid for the ...
Cotteleer, G., Peerlings, J.H.M.
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Post-Earthquake Urban Planning in Türkiye: Evaluating Disaster Refuge Systems in Hatay and Istanbul

Journal of Architectural Sciences and Applications
Countries prone to significant earthquakes often develop disaster refuge and relief urban park systems to enhance urban open green spaces, which serve as temporary shelters for evacuation after seismic events.
Büşra Nur Gök, Gizem Dinç
doaj   +1 more source

ÁREAS VERDES URBANAS, ESPAÇOS LIVRES PARA O LAZER / Urban green areas, open spaces for leisure [PDF]

Sociedade & Natureza, 2007
The creation and the management of Conservation Units in urban areas, as in the category ofintegral protection as of sustainable use, aims to improve the quality of life of the urban citizenat the same time that it promotes an improvement in the urban ...
Kátia MAZZEI Mazzei, Marlene T. Muno Colesanti, Douglas Gomes dos Santos   +2 more
doaj  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Prospect Green Map: a community map of environmental, historical, cultural, civic, and recreational sites

A map detailing the sites of interest and importance in the Prospect, NC, and the Robeson County area of North Carolina.
Robeson County Green Map Project
core   +1 more source

Urban Spatial Naturalness Degree in the Planning of Ultra-High-Density Cities: The Case of Urban Green Open Spaces in Macau

Buildings
This study deeply examines the livable environment in high-density cities like Macau, focusing on urban green spaces. The study introduces the “urban spatial naturalness degree” indicator, exploring its application with urban population growth and green ...
Jitai Li, Fan Lin, Hongcan Cui, Shuai Yang, Yile Chen   +4 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source