Results 131 to 140 of about 23,246,767 (284)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Needs analysis for public green spaces in Grosuplje [PDF]

Urbani Izziv, 2008
A huge increase in residential and business-commercial construction has characterised Grosuplje, a young town and suburban settlement of the greater Ljubljana area, over the last two decades, thereby increasing the number of possible users of its open ...
Klara Sulič, Ana Kučan
doaj  

The effect of urban open green areas on carbon footprint

Urban open green areas are the most important component of urban planning. A city's ability to live in a philosophy that is compatible with ecological principles and takes into account natural processes depends on the correct planning of open green areas.
Demiroğlu, Demet, Karadağ, Aybike Ayfer, Kurtaslan, Banu Öztürk, Ermiyagil, Selen Abbasoğlu   +3 more
openaire   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

A study about relationship between urban pattern and open green areas in Karşıyaka district

, 2003
Bu çalışma, açık-yeşil alanlar temelinde, yaşanabilir kent dokusu modeli için bir adım oluşturma amacını hedeflemektedir. Böylece, açık-yeşil alan standartları, gelişmiş ülkeler düzeyinde ele alınarak, yaşanabilir kent olgusu ilişkileri çerçevesinde ...
Erdem, Ümit, Yiğiter, Sibel
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Índices de área verde y cobertura vegetal para la ciudad de Parral (Chile), mediante fotointerpretación y SIG

Ciência Florestal, 2011
The importance of the green areas is increasing since they are an important factor in the health and welfare of urban population. Therefore, in Parral city, in Central Chile, it was quantified and analyzed the availability of green areas and vegetation ...
Carlos Mena, Yony Ormazábal, Yohana Morales, Rómulo Santelices, John Gajardo   +4 more
doaj  

Externalities Imposed on Residential Properties in Highly Urbanized Areas [PDF]

, 2008
In highly industrialized areas open spaces such as farmland and nature are under pressure since urban areas are expanding at their expense. Because of the high opportunity costs of development in urban areas, a high price has to be paid for the ...
Cotteleer, G., Peerlings, J.H.M.
core