Results 111 to 120 of about 21,611,408 (294)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Worldwide open access: UK leadership?

, 2013
The web is destined to become humankind's cognitive commons, where digital knowledge is jointly created and freely shared. The UK has been a leader in the global movement toward open access (OA) to research but recently its leadership has been derailed ...
Stevan Harnad, Harnad, Stevan
core   +1 more source

Investigation Open and Green Areas Existence in The Boundaries of Protected Area of Edirne City

, 2015
The need of housing has raised within the increase of population and cities have development in unplanned way during the urbanization process. Being one of significant requirement of people, the importance of open and green spaces have increased during ...
Korkut, A. B., Aytin, B. Karakaya
core   +1 more source

Analysis of the impact of opening and sharing of affiliated green spaces on the accessibility and equal access of green spaces: a case study in Shanghai

Discover Sustainability
Within the context of limited land resources in densely populated urban areas, the opening and sharing of affiliated green spaces have become an innovative way to expand urban green spaces.
Jinyue Yang, Sijun Zheng, Shengpeng Wang, Ruijun Hao, Tintin Fu, Kun He, Ming Yin, Wenqian Ma, Qian Xie   +8 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

How Do Homebuyers Value Different Types of Green Space? [PDF]

It is important to understand tradeoffs in preferences for natural and constructed green space in semi-arid urban areas because these lands compete for scarce water resources.
Osgood, Daniel E., Bark, Rosalind H., Halper, Eve B., Colby, Bonnie G.   +3 more
core  

Local Government Open Space Funding Programs in New Jersey: Results of a Survey Conducted by the Green Acres Program

, 1998
This report contains the results of the second annual Green Acres survey of local government open space funding programs. In this report, the term open space refers to both parkland and farmland. Parkland encompasses developed parks, conservation lands,

core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Open and green areas Soma (Manisa) district determining potential [PDF]

, 2010
Fen Bilimleri Enstitüsü, Peyzaj Mimarlığı Ana Bilim DalıHızlı kentleşme, sanayileşme ve artan nüfus, mekânlarda yapılaşmaların artmasına, açık-yeşil alanların miktarının giderek azalmasına neden olmakta ve bunun sonucu kentli doğadan hızla kopmaktadır ...
Günal, İlknur
core   +1 more source