Results 81 to 90 of about 21,611,408 (294)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Use of GIS Technology for Distribution of City Forests and Green Open Spaces

Jurnal Teknologi Informatika & Komputer
Metro City, as one of the urban areas in Indonesia, faces big challenges in managing and maintaining the balance of the urban ecosystem. Green Open Space (RTH) and City Forests have a strategic role in supporting ecosystem sustainability through ...
Nur Zailani, Budi Sutomo
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Strategic Planning of Surabaya City Government in Managing Public Green Open Space (A Study at the Surabaya City Sanitation and Green Open Space Agency)

Jurnal Pembangunan dan Alam Lestari, 2020
Public Green Open Space is one of the important components in managing cities in order to realize the mandate of Law Number 26 of 2007 concerning Spatial Planning, namely the proportion of Public Green Open Space in city areas of at least 20% of the ...
Oktarizka Reviandani, Soesilo Zauhar, Endah Setyowati   +2 more
doaj  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Green áreas of Guarulhos/São Paulo: classification and quantification

GEOUSP: Espaço e Tempo, 2000
Among corporations of research, education and planning we find different versions of term s for green area, open space, tree canopy coverage, areas destined to nature conservation, etc.
João Carlos Nucci, Marcos Pereira Lopes, Fernanda Pereira de Campos, Ueverson Martins Alves, Márcio Mantovani   +4 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Uganda Protected Areas

This Shapefile is an overview of all of the Protected Areas of Uganda based on information provided by Protected Planet. This includes 712 Polygons/Points Ratio and includes 10 National Parks, 661 Forest Reserves, 7 Wildlife Sanctuaries, 12 Wildlife ...
Open Sustainability Institute
core   +2 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source