Results 91 to 100 of about 22,030,632 (238)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Optimization of green open space in Ambon City

, 2022
The increase in population in Ambon City has resulted in increased space requirements and impacts the conversion of green areas into built-up areas. This indirectly impacts the decline in environmental quality, marked by an increase in the concentration ...
Selanno, F.M., Santoso, P., Arinah, H., Sitanala, M.R.   +3 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Post-Earthquake Urban Planning in Türkiye: Evaluating Disaster Refuge Systems in Hatay and Istanbul

Journal of Architectural Sciences and Applications
Countries prone to significant earthquakes often develop disaster refuge and relief urban park systems to enhance urban open green spaces, which serve as temporary shelters for evacuation after seismic events.
Büşra Nur Gök, Gizem Dinç
doaj   +1 more source

Sacred places in public open green areas [PDF]

, 2018
W artykule zaprezentowano różne wzory projektowania sacrum w zielonych przestrzeniach publicznych, jak również Uniwersalny wzorzec parku o właściwościach terapeutycznych.
Trojanowska, M.
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Open and green areas Soma (Manisa) district determining potential [PDF]

, 2010
Fen Bilimleri Enstitüsü, Peyzaj Mimarlığı Ana Bilim DalıHızlı kentleşme, sanayileşme ve artan nüfus, mekânlarda yapılaşmaların artmasına, açık-yeşil alanların miktarının giderek azalmasına neden olmakta ve bunun sonucu kentli doğadan hızla kopmaktadır ...
Günal, İlknur
core   +1 more source