Results 151 to 160 of about 40,814,819 (270)

G2DR: a genotype-first framework for genetics-informed target prioritization and drug repurposing. [PDF]

Brief Bioinform
Muneeb M, Ascher DB.
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Why Linked Data is Not Enough for Scientists

—Scientific data stands to represent a significant portion of the linked open data cloud and science itself stands to benefit from the data fusion capability that this will afford.
Delderfield, Mark, De Roure, David, Gamble, Matthew, Sufi, Shoaib, Bhagat, Jitenkumar, Owen, Stuart, Michaelides, Danius, Cruickshank, Don, Ainsworth, John, Buchan, Iain, Couch, Phillip, Dunlop, Ian, Missier, Paolo, Newman, David, Goble, Carole, Bechhofer, Sean   +15 more
core   +1 more source

Enhanced Health Study Discoverability: Graph-Based Analysis Approach. [PDF]

JMIR Med Inform
Gütebier L, Groß S, Winter B, Blumenstock M, Dugas M, Liebscher V, Waltemath D, Henkel R.   +7 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Operationalising neuroinclusive work systems: A multi-method framework for organisational research. [PDF]

MethodsX
Tootell B, Rao V.
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Bibliographic control and linked open data : the challenge of the bibliographic framework initiative

Bibliographic control and linked open data : the challenge of the bibliographic framework initiative
同志社大学図書館司書課程 特別講演会記録（英文記録）
openaire   +1 more source

CATVariant: a web server for integrated protein variant interpretation across sequence, structure, population, and clinical evidence. [PDF]

Nucleic Acids Res
Ngo K, Amini H, Vorobyov I, Clancy CE.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source