Results 111 to 120 of about 1,007,234 (319)
Legitimately diverse, yet comparable: Synthesising social inclusion performance in the EU. [PDF]
The Open Method of Coordination (OMC) intends to enhance EU member states’ performance with regard to social inclusion. In this context a set of commonly agreed performance indicators plays an important role.
Cherchye, Laurens +2 more
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The 'Open Method of Coordination' as an Instrument for Implementing the Principle of Subsidiarity? WP C.S.D.L.E. "Massimo D'Antona" N. 33/2005 [PDF]
, 2005 [From the Introduction]. Since the Treaty of Maastricht (1992), later incorporated in the Treaty of Amsterdam (1997), the concept of ‘subsidiarity’ has become a prominent part of the constitutional order of the European Union.
Kohl, Jurgen, Vahlpahl, Tobias.
core
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Research Progress and Typical Case of Open-Pit to Underground Mining in China
Applied SciencesAs Chinese open-pit mines progressively transition to deeper operations, challenges such as rising stripping ratios, declining slope stability, and environmental degradation have become increasingly pronounced.
Shuai Li +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Decision Making and Learning in a Globalizing World [PDF]
Decision-makers can benefit from the experience of others with solutions to common problems. If a best practice exists, the challenge is to recognize it and to ensure its diffusion.
Bauke Visser, Otto H. Swank
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Conductance through atomic point contacts between fcc(100) electrodes of gold
, 2008 Electrical conductance through various nanocontacts between gold electrodes is studied by using the density functional theory, scalar-relativistic pseudopotentials, generalized gradient approximation for the exchange-correlation energy and the recursion ...
Häkkinen, H. +2 more
core +2 more sources