Results 111 to 120 of about 168,982,903 (290)
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
SSM: Qualitative Research in HealthHealthcare systems are increasingly challenged by multimorbid patient trajectories that cut across specialized, siloed units, which introduces significant complexity that demands highly coordinated, adaptive efforts.
Johanna Torres-Bonilla +2 more
doaj +1 more source
Open Method of Coordination as a Europeanization Tool
Czech Journal of Political Science/Politologický časopis, 2009 The study analyzes the Open Method of Coordination phenomenon, which has over the last decade become a prominent representative of the “soft-law” approach to EU law-making and integration in general, with respect to its Europeanizing potential. It therefore seeks to answer the question whether it this method of governance can be considered a new (and ...
openaire +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
IEEE AccessExisting research and public reports on state-sponsored or state-directed Advanced Persistent Threats (APTs) describe adversary behavior mainly through tools, tactics, techniques, and procedures, but are less explicit about how long-running operations ...
Dalibor Gernhardt +2 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Space, place and scale: reframing the open method of co-ordination for ‘Education and Training 2010’
, 2007 In this paper I argue that we can usefully address the nature, significance and range of effects of the OMC for Education and Training by adopting the theoretical perspectives on space, place and scale from the fields of economic geography and state ...
Jones, Peter D.
core +1 more source
Research Progress and Typical Case of Open-Pit to Underground Mining in China
Applied SciencesAs Chinese open-pit mines progressively transition to deeper operations, challenges such as rising stripping ratios, declining slope stability, and environmental degradation have become increasingly pronounced.
Shuai Li +4 more
doaj +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source