Results 131 to 140 of about 8,213,046 (356)
Discover SustainabilityIn today’s intensifying global economic competition, countries cannot immediately reallocate resources to moderate environmental and societal losses. The imbalance in the distribution of social resources also causes the government to face a series of ...
Hao Yen Tran +5 more
doaj +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
An open chat with… Johannes Herrmann
FEBS Open BioJohannes Herrmann is a Professor of Cell Biology at the University of Kaiserslautern in Germany. His research focus is centred on the biogenesis of mitochondrial proteins.
Ioannis Tsagakis, Johannes Herrmann
doaj +1 more source
HeliyonGlobal organizations are still facing challenges in achieving sustainable performance despite the surge in digital technologies. It is imperative that firms invest in digital capabilities to secure sustainable market performance in the face of a barrage ...
Aixia Chen, Ling Li, Waseem Shahid
doaj +1 more source
Hulk Smash”™ Busting the OAA Silo! [PDF]
, 2015 This poster focuses on Lavery Library’s collaboration with the Office of Academic Affairs, OAA. At St. John Fisher College students with learning disabilities testing accommodations take their exams in the library instead of a testing center.
Celata, Stacy
core +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Door Hanger - Open Access Week at Gettysburg College
, 2014 This print marketing piece was designed to complement online promotion of Open Access Week 2014 at Gettysburg College. Door hangers provide a brief description of OA Week events aimed at faculty.
Musselman Library,
core