Results 111 to 120 of about 779,176 (309)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Open Source for Digital Curation [PDF]

, 2005
This Curation Manual instalment discusses at some lengths the relevant strengths of open source software from a digital curation perspective, as well as detailing some of its more general advantages, which must be understood in order to accept the ...
McHugh, Mr Andrew, McHugh, Andrew
core  

Unpacking GenAI-enabled deep learning engagement: role perceptions, human–GenAI synergy strategies, and underlying mechanisms

Frontiers in Psychology
BackgroundGenerative AI is rapidly transforming how students learn, yet its impact on deep learning varies significantly among individuals. This study investigates the mechanisms linking students’ role perception of GenAI, their human–GenAI synergy ...
Qian Gao, Hui Zhou, Hang Lu
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Beyond individual traits: differential associations of social support profiles with resilience in older learners

Frontiers in Psychology
BackgroundLifelong learning is a vital pathway for fostering social integration and psychological well-being among older adults. This study examines the differential associations of social support and challenge patterns with resilience in older learners ...
Qian Gao, Hui Zhou, Hang Lu
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

An econometric analysis of Shanghai office rents

, 2009
The modern commercial office market in Shanghai emerged with China’s economic reform and open door policy in the 1980s and grew rapidly at the beginning of 1990s,with increasing demand for office space from foreign and domestic occupiers.
White, Michael, Ke, Qiulin, Ke, Q, White, M   +3 more
core   +1 more source

PRS Global Open: A Dream Turning to Reality

Plastic and Reconstructive Surgery, Global Open, 2020
Rod J. Rohrich, MD, Aaron G. Weinstein, MS, Isiah Donnell Moore, BA, James M. Stuzin, MD   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source