Results 111 to 120 of about 20,084,391 (297)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Unpacking GenAI-enabled deep learning engagement: role perceptions, human–GenAI synergy strategies, and underlying mechanisms

Frontiers in Psychology
BackgroundGenerative AI is rapidly transforming how students learn, yet its impact on deep learning varies significantly among individuals. This study investigates the mechanisms linking students’ role perception of GenAI, their human–GenAI synergy ...
Qian Gao, Hui Zhou, Hang Lu
doaj   +1 more source

Creation conditions of open-plan office interior

, 2018
Diplomdarbs “Atvērta plānojuma biroja interjera izveides nosacījumi” sastāv no trīs nodaļām. Pirmajā nodaļā tiek aprakstīta atvērta plānojuma rašanās, atvērta plānojuma biroju vēsture, tā plusi un mīnusi, problēmas un to novēršanas iespējas, aktuālās ...
Ķikute, Santa
core  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

PRS Global Open: A Dream Turning to Reality

Plastic and Reconstructive Surgery, Global Open, 2020
Rod J. Rohrich, MD, Aaron G. Weinstein, MS, Isiah Donnell Moore, BA, James M. Stuzin, MD   +3 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Virtuelt skrivebord med open office

, 2009
SDUs erfaringer med projektet Port 22: en virtuel platform med Open Office som kontorpakke til ...
Nielsen, Kurt Gammelgaard
core   +1 more source

Beyond individual traits: differential associations of social support profiles with resilience in older learners

Frontiers in Psychology
BackgroundLifelong learning is a vital pathway for fostering social integration and psychological well-being among older adults. This study examines the differential associations of social support and challenge patterns with resilience in older learners ...
Qian Gao, Hui Zhou, Hang Lu
doaj   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source