Results 151 to 160 of about 8,213,046 (356)

Doe Dose

open access: yes, 2014
A plastic fawn, palm-sized, lives on my office desk. He gazes at my open office door. His right front hoof is raised, poised for haste. The deer of my Mississippi childhood were the Virginia whitetail, Odocoileus virginianus virginianus.
Stephenson, Sharon L.
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Online No Child Left Behind Survey Responses from Mississippi vs. the National Average [PDF]

open access: yes, 2005
The PEN national office launched a 2005 No Child Left Behind (NCLB) online survey to follow up on the 2004 survey. The 2004 survey generated 12,000 responses and greatly influenced the recommendations in the "Open to the Public" report released in March ...

core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

COVID-19 outbreak: Closure of office versus open office with postponed long holidays

open access: yesMedical Journal of Dr. D.Y. Patil Vidyapeeth, 2021
Beuy Joob, Viroj Wiwanitkit
doaj   +1 more source

25425 & 20500: ZIP codes for a Revolution [PDF]

open access: yes, 2013
I put on my coat and headed out the door today around lunchtime. My excuse was to grab a sandwich to munch on at my desk, but I was really hunting something very different.
Rudy, John M.
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

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