Results 181 to 190 of about 510,176 (216)

A Single‐Amino‐Acid Ligand for LAT1: A Minimalist and Modular Platform for Lysosome‐Targeted Degradation of Membrane Proteins

open access: yesAdvanced Science, EarlyView.
LA‐LYTAC repurposes the cancer‐enriched amino acid transporter LAT1 as a lysosomal trafficking receptor for targeted membrane‐protein degradation. A single phenylalanine‐derived ligand, modularly linked to antibodies or small‐molecule binders, recruits PD‐L1, EGFR, or integrins to LAT1, triggering transporter‐mediated internalization, lysosomal ...
Liquan Zhu   +12 more
wiley   +1 more source

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

open access: yesAdvanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu   +4 more
wiley   +1 more source

A high-resolution, multi-method palaeoenvironmental record from pan sediments at Maralaleng Pan, southern Kalahari basin. [PDF]

open access: yesPLoS One
Faul I   +10 more
europepmc   +1 more source

Spontaneously Piezo- and Pyroelectric Polyacrylonitrile Brushes Prepared via Surface-Initiated Polymerization. [PDF]

open access: yesJ Am Chem Soc
Hu F   +7 more
europepmc   +1 more source

A Case of Primary Intramedullary Infantile Fibrosarcoma With an RBPMS::NTRK3 Fusion and Response to Larotrectinib. [PDF]

open access: yesNeuropathol Appl Neurobiol
Le Quang M   +8 more
europepmc   +1 more source

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