Results 251 to 260 of about 16,682,348 (303)

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An   +8 more
wiley   +1 more source

Engineered Au@CeO2 Hybrid Nanoparticles With Microenvironment Dependent Self‐Adjustability for Integration of Tumor‐Specific Photothermal‐Chemodynamic Therapy and Inflammation Prevention

open access: yesAdvanced Science, EarlyView.
An intelligent Au@CeO2 Hybrid Nanoparticles (ACEF) with microenvironment‐dependent self‐adjustability was engineered to not only perform efficient and tumor‐specific photothermal‐chemodynamic therapy for precise tumor elimination, but also serve as a ROS scavenger in healthy tissues around the tumor to avoid the unexpected oxidative damage and ...
Wenyun Mu   +8 more
wiley   +1 more source

Impacted Bones: Can Extant Primates Help Identify Tool Use in Early Hominins? [PDF]

open access: yesEvol Anthropol
Hurwitz RM   +3 more
europepmc   +1 more source

Generative AI-Assisted Indication of Anatomical Landmarks to Enhance Safety under Intraoperative Bleeding in Laparoscopic Gastrectomy for Gastric Cancer. [PDF]

open access: yesAnn Surg Open
Fujishima R   +10 more
europepmc   +1 more source

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