Results 71 to 80 of about 68,272 (311)

Analysis of development situation and countermeasures of high quality safety in open-pit coal mines

open access: yes, 2022
In order to further promote the development of open-pit coal mines with high quality and safety, increase the proportion of open-pit coal output, and enhance the overall level of safety production in China’s coal mines, the analysis of the development ...
ZHAO Hao
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Modelling Open Pit Dynamics Using Discrete Simulation

open access: yes, 2007
The objective in any mining operation is to exploit ore at the lowest possible cost with the prospect of maximizing profits. The planning of an open pit mine is an economic exercise, constrained by certain geological, operating, technological and local ...
Askari-Nasab, H.   +2 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Optimisation of open pit mine block sequencing

open access: yes, 2015
This study presents a comprehensive mathematical model for open pit mine block sequencing problem which considers technical aspects of real-life mine operations.
Mousavi Nogholi, Amin Alah
core  

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

Mathematical Model for Flexible Allocation of Multi-Capacity Trucks in Open Pit Mines

open access: yes, 2005
The objective of flexible allocation of trucks is to increase the productivity of haulage system. In this paper, a comprehensive model is produced for the haulage system in open pit mines, which can optimize the allocation process of trucks by goal ...
Ahmadi, Morteza   +2 more
core  

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

open access: yesFEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Hydrocarbon generation potential evaluation of high–over mature Permian source rocks in the Southwestern part of the central depression, Junggar Basin

open access: yesPetroleum
A comprehensive study was conducted on the hydrocarbon generation potential of the deeply buried Permian source rocks with high–over mature in the southwestern part of the Central Depression, Junggar Basin.
Chenyu Wang   +8 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

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