Results 181 to 190 of about 991,153 (346)

The influence of psychosocial factors on productivity when implementing new office designs - a longitudinal explorative study in the Swedish public sector. [PDF]

BMC Public Health
Stöllman Å, Svartengren M, Lampa E, Nyman T.   +3 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Facility newborn and stillbirth data use and enabling factors at different levels of the health system: findings of the IMPULSE study across 142 sites in the Central African Republic, Ethiopia, Tanzania, and Uganda. [PDF]

J Glob Health
Abathun F, Dalena P, Kananura RM, Minja J, Mouhamadou O, Ayele M, Day LT, Tognon F, Cora LG, Mariani I, Geremia S, Putoto G, Lawn JE, Awel T, Bundala F, Shamba D, Waiswa P, Lazzerini M.   +17 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Evaluating TOD performance through node-place model: evidence from bus stop areas in Windhoek, Namibia. [PDF]

Front Public Health
Cui N, Yang H, Mwetuhafifa NM.
europepmc   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Functionalities of electronic routine health information systems related to newborn data: findings of the IMPULSE study in Uganda, Ethiopia, Tanzania, and the Central African Republic. [PDF]

J Glob Health
Ayele M, Mariani I, Abathun F, Mouhamadou O, Minja J, Rornald MK, Tognon F, Day LT, Sæbø J, Fisseha H, Bundala F, Dalena P, Geremia S, Cora LG, Lawn JE, Putoto G, Waiswa P, Shamba D, Lazzerini M.   +18 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Organisational and management factors and related end-users' perspectives relevant to newborn and stillbirth data at different levels of the health system: findings of the IMPULSE study in Uganda, Ethiopia, Tanzania, and the Central African Republic. [PDF]

J Glob Health
Mariani I, Abathun F, Mouhamadou O, Minja J, Kananura RM, Tognon F, Ayele M, Putoto G, Awell T, Dalena P, Geremia S, Cora LG, Day LT, Shamba D, Waiswa P, Lazzerini M.   +15 more
europepmc   +1 more source