Results 191 to 200 of about 991,153 (346)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Invisible scars and trauma: The psychological cost of youth-led protests in Nepal and the global imperative for trauma‑responsive mental-health systems. [PDF]

PLOS Ment Health
Paudel S, Chalise A, Yadav UN.
europepmc   +1 more source

Deep learning for predictive window operation modeling in open-plan offices

Energy and Buildings
Farzan Banihashemi, Manuel Weber, Werner Lang   +2 more
semanticscholar   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Understanding safety measure practices and improvement strategies among health professionals in resource-limited health care settings in the Awi Zone, Amhara, Ethiopia: a qualitative study. [PDF]

BMJ Open
Ayalew AF, Delie AM, Fornah L, Shimbre MS, Ma W.   +4 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Implementation and sustainability of mentorship for public health student success. [PDF]

Front Public Health
Grilo SA, Joseph MA, Samari G.
europepmc   +1 more source

Gateways to Gloucestershire's past [PDF]

, 2004
Calver, S.J., Johnston, Nicky
core  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Consequences of United States funding suspensions on community-led HIV services in Latin America and the Caribbean: findings of a rapid service provider survey. [PDF]

J Int AIDS Soc
Guillén JR, Stevenson M, Talero MÁB, Torres MA, Wirtz AL.   +4 more
europepmc   +1 more source