Results 171 to 180 of about 780,027 (226)

High-quality peptide evidence for annotating non-canonical open reading frames as human proteins

Deutsch EW, Kok LW, Mudge JM, Ruiz-Orera J, Fierro-Monti I, Sun Z, Abelin JG, Alba MM, Aspden JL, Bazzini AA, Bruford EA, Brunet MA, Calviello L, Carr SA, Carvunis A, Chothani S, Clauwaert J, Dean K, Faridi P, Frankish A, Hubner N, Ingolia NT, Magrane M, Martin MJ, Martinez TF, Menschaert G, Ohler U, Orchard S, Rackham O, Roucou X, Slavoff SA, Valen E, Wacholder A, Weissman JS, Wu W, Xie Z, Choudhary J, Bassani-Sternberg M, Vizcaíno JA, Ternette N, Moritz RL, Prensner JR, van Heesch S.   +42 more
europepmc   +1 more source

RNA-binding protein Nocte regulates Drosophila development by promoting translation reinitiation on mRNAs with long upstream open reading frames. [PDF]

Nucleic Acids Res
Zhang T, Xue Y, Su S, Altouma V, Ho K, Martindale JL, Lee SK, Shen W, Park A, Zhang Y, De S, Gorospe M, Wang W.   +12 more
europepmc   +1 more source

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Small Open Reading Frames

Resonance, 2018
A. Yazhini
semanticscholar   +2 more sources

Translation of Small Open Reading Frames: Roles in Regulation and Evolutionary Innovation.

Trends in Genetics, 2019
The translatome can be defined as the sum of the RNA sequences that are translated into proteins in the cell by the ribosomal machinery. Until recently, it was generally assumed that the translatome was essentially restricted to evolutionary conserved ...
Jorge Ruiz-Orera, M. Albà
semanticscholar   +1 more source

The Definition of Open Reading Frame Revisited

Trends in Genetics, 2018
The term open reading frame (ORF) is of central importance to gene finding. Surprisingly, at least three definitions are in use. We discuss several molecular biological and bioinformatics aspects, and we recommend using the definition in which an ORF is bounded by stop codons.
Patricia Sieber, Matthias Platzer, Stefan Schuster   +2 more
openaire   +2 more sources

Inferring genes from open reading frames

Computers & Chemistry, 1994
One expects that in DNA without protein coding function, stop codons (which constitute three of the 64 possible codons) should occur frequently in all reading frames, and that a long open reading frame (ORF) can be interpreted as a sign for the existence of a gene.
openaire   +2 more sources

Bioprospecting Open Reading Frames for Peptide Effectors

2013
Recent successes in the development of small-molecule antagonists of protein-protein interactions designed based on co-crystal structures of peptides bound to their biological targets confirm that short peptides derived from interacting proteins can be high-value ligands for pharmacologic validation of targets and for identification of druggable sites.
Ling, Xiong, Charles, Scott
openaire   +2 more sources

Coupling of Open Reading Frames by Translational Bypassing

Annual Review of Biochemistry, 2000
▪ Abstract  Translational bypassing joins the information found within two disparate open reading frames into a single polypeptide chain. The underlying mechanism centers on the decoding properties of peptidyl-transfer RNA (tRNA) and involves three stages: take-off, scanning, and landing.
A J, Herr, J F, Atkins, R F, Gesteland
openaire   +2 more sources