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The Definition of Open Reading Frame Revisited
Trends in Genetics, 2018The term open reading frame (ORF) is of central importance to gene finding. Surprisingly, at least three definitions are in use. We discuss several molecular biological and bioinformatics aspects, and we recommend using the definition in which an ORF is bounded by stop codons.
Patricia Sieber +2 more
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Inferring genes from open reading frames
Computers & Chemistry, 1994One expects that in DNA without protein coding function, stop codons (which constitute three of the 64 possible codons) should occur frequently in all reading frames, and that a long open reading frame (ORF) can be interpreted as a sign for the existence of a gene.
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Bioprospecting Open Reading Frames for Peptide Effectors
2013Recent successes in the development of small-molecule antagonists of protein-protein interactions designed based on co-crystal structures of peptides bound to their biological targets confirm that short peptides derived from interacting proteins can be high-value ligands for pharmacologic validation of targets and for identification of druggable sites.
Ling, Xiong, Charles, Scott
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Coupling of Open Reading Frames by Translational Bypassing
Annual Review of Biochemistry, 2000▪ Abstract Translational bypassing joins the information found within two disparate open reading frames into a single polypeptide chain. The underlying mechanism centers on the decoding properties of peptidyl-transfer RNA (tRNA) and involves three stages: take-off, scanning, and landing.
A J, Herr, J F, Atkins, R F, Gesteland
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Engineering crop performance with upstream open reading frames
Trends in Plant SciencePlants intricately regulate the expression of protein-coding genes at multiple stages - including mRNA transcription, translation, decay, and protein degradation - to control growth, development, and responses to environmental challenges. Recent research highlights the importance of translational reprogramming as a pivotal mechanism in regulating gene ...
Rui Mou +3 more
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Open reading frames and translational control
Nature, 1988Kessel, M., Gruss, P.
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Generation of overlapping open reading frames
Trends in Genetics, 1996S, Cebrat, M R, Dudek
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Patterning Wettability for Open-Surface Fluidic Manipulation: Fundamentals and Applications
Chemical Reviews, 2022Pallab Sinha Mahapatra +2 more
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