Results 51 to 60 of about 16,981,451 (257)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Surgical Management of Inguinal Hernias at Bugando Medical Centre in Northwestern Tanzania: Our Experiences in a Resource-Limited Setting. [PDF]

, 2012
Inguinal hernia repair remains the commonest operation performed by general surgeons all over the world. There is paucity of published data on surgical management of inguinal hernias in our environment.
Joseph B Mabula, Chalya, Phillipo L, Phillipo L Chalya, Mabula, Joseph B, Mabula Joseph B, Chalya Phillipo L   +5 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Laparoscopic versus open emergency repair for strangulated abdominal wall hernias: a propensity-score-matched retrospective cohort study

Frontiers in Surgery
Background and objectivesThe optimal surgical approach for incarcerated or strangulated abdominal wall hernias remains debated. While laparoscopic techniques are well established electively, evidence on their emergency-setting role is limited. This study
Ahmet Topcu, İsmail Ege Subaşı, Furkan Saydin   +2 more
doaj   +1 more source

Contemporary Strategies in the Management of Civilian Neck Zone II Vascular Trauma

Frontiers in Surgery, 2017
Neck trauma is the leading cause of death mainly in younger persons posing to surgeons the dilemma whether to proceed with reconstruction of vascular injuries either in the presence of coma or in severe neurological deficit.
Georgios Karaolanis, Konstantinos Maltezos, Chris Bakoyiannis, Sotiris Georgopoulos   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Observations from the IMPROVE trial concerning the clinical care of patients with ruptured abdominal aortic aneurysm. [PDF]

, 2013
BACKGROUND: Single-centre series of the management of patients with ruptured abdominal aortic aneurysm (AAA) are usually too small to identify clinical factors that could improve patient outcomes.
Hinchliffe, RJ, Thompson, MM, Bell, R, Greenhalgh, R. M., Ashleigh, R., Grieve, RJ, Ulug, P., Heatley, F., Powell, JT, Sweeting, M. J., Ashleigh, R, Heatley, F, Thompson, S. G., Powell, J. T., Greenhalgh, RM, Gomes, M, Ulug, P, Sweeting, MJ, Gomes, M., ?, ?, Thompson, SG, Hinchliffe, R. J., IMPROVE trial investigators, Thompson, M. M., Bell, Rachel, Grieve, R. J.   +25 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Endonuclease V-Mediated Deoxyinosine Excision Repair in Vitro

, 2011
Deoxyinosine (dI) in DNA can arise from hydrolytic or nitrosative deamination of deoxyadenosine It is excised in a -repair pathway that is initiated by endonuclease V.
楊雅倩;林淑萍;高照村;蔡克嵩;方偉宏, YANG, YA-CHIEN;STEVEN, D. GOODMAN;LIN, SHWU-BIN;KAO, JAU-TSUEN;TSAI, KEH-SUNG;FANG, WOEI-HORNG   +1 more
core   +1 more source