Results 201 to 210 of about 15,014,800 (402)
Bootstrapping the Open Science culture: The fellowship approach [PDF]
Sigrid Fahrer+3 more
openalex +1 more source
How to build an Open Science Monitor based on publications? A French perspective [PDF]
Many countries and institutions are striving to develop tools to monitor their open science policies. Since 2018, with the launch of its National Plan for Open Science, France has been progressively implementing a monitoring framework for its public policy, relying exclusively on reliable, open, and controlled data.
arxiv
Solving medicine’s data bottleneck: Nightingale Open Science
S. Mullainathan, Z. Obermeyer
semanticscholar +1 more source
{"references": ["A. Huebl et al. openPMD 1.0.0: A meta data standard for particle and mesh based data, technical specification (CC-BY 4.0), November 2015, DOI:10.5281/zenodo.33624", "A. Huebl et al. On the Scalability of Data Reduction Techniques in Current and Upcoming HPC Systems from an Application Perspective, ISC 2017, arXiv:1706.00522", "H ...
Huebl, Axel+6 more
openaire +4 more sources
We achieved cytoplasmic delivery of non‐cell‐penetrating IgGs by grafting a single functional complementarity‐determining region 1 (CDR1) from the light chain variable region (VL) of the cell‐internalizable 3D8 antibody. The engineered IgG acquired cell‐penetrating ability while maintaining antigen affinity, highlighting CDR1 grafting as a promising ...
Yerin Jeon+5 more
wiley +1 more source
A Book That Begs for a Science Open to Speak Outside its Customary Lines [PDF]
F.M. Mealing
openalex +1 more source
Contextualizing Openness: Situating Open Science.
Zenodo (2019).
Chan, Leslie+4 more
openaire +4 more sources
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner+7 more
wiley +1 more source
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source