Results 81 to 90 of about 2,214,920 (300)
The Eight National Information Day: Open Science, Open Data, Open Access
Digital Presentation and Preservation of Cultural and Scientific Heritage, 2017 The paper draws current state of Bulgarian Open access (OA) activities and discussion points for the Eight National Information Day: Open Science, Open Data, and Open ...
Peter L. Stanchev +4 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
The Ninth National Information Day: Open Science, Open Data, Open Access
Digital Presentation and Preservation of Cultural and Scientific Heritage, 2018 The paper draws current state of Bulgarian Open access (OA) activities and discussion points for the Ninth National Information Day: Open Science, Open Data, and Open Access.
Peter Stanchev +6 more
doaj +1 more source
Science AMA Series: We are 3 scientists who are collaborating on an open science project to find treatments for Zika. Ask Us Anything! [PDF]
, 2016 Open Zika, r Science
openalex +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Exchanges, 2016 Science is the best method humanity has for understanding the universe and our place in it. However, despite its astonishing achievements, the implementation and communication of science is not without problem.
Liam J. Messin, John C. Meadows
doaj
Bulgarian Open Science Digital Library - First Prototype
Digital Presentation and Preservation of Cultural and Scientific Heritage, 2019 In this paper we present the process of development of Bulgarian Open Science Digital Library (BOSDL) as the first and main ingredient of Bulgarian Open Science Cloud (BOSC). We introduce and discuss main principles involved in the Open Science movement.
Atanas Georgiev, Krassen Stefanov
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source