Results 111 to 120 of about 1,045,429 (295)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Frontiers in NutritionBackgroundDietary behavior is affected by various factors and adverse dietary behavior is a risk factor for stroke recurrence. The current study examined the relationship between dietary behavior and relevant situational factors in stroke patients during
Weiying Zhong +7 more
doaj +1 more source
Taxation by Auction: Fund-Raising by 19th Century Indian Guilds [PDF]
We describe a unique institution used by 19th century Indian guilds to raise funds: The guild members agreed that on a particular day all but one of their shops would be shut.
Anand V. Swamy, Arijit Sen
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
From new clones to flowers – innovative business models in the Hungarian wine economy
BIO Web of Conferences, 2017 Due to the ovestocked Hungarian wine sector wineries often need to find entirely new ways that enable them to increase their market share. These opportunities are determined by the current market potentials, the geographic location and of course the wine
Kismarjai Balázs
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
AlgorithmsThis paper presents a novel, multi-objective scatter search algorithm (MOSS) for a bi-objective, dynamic, multiprocessor open-shop scheduling problem (Bi-DMOSP). The considered objectives are the minimization of the maximum completion time (makespan) and
Tamer F. Abdelmaguid
doaj +1 more source
Who Will Build the Future? [PDF]
, 1988 [Excerpt] The construction unions\u27 crisis both preceded and contributed to the general decline of organized labor. At the time concessions became a household word in manufacturing, building trades workers had already endured five years of wage ...
Erlich, Mark
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source