Results 51 to 60 of about 42,475 (265)

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Pre-rerouting Strategy to Ensure Business Continuity for Low-Earth-Orbit Satellite Network

Space: Science & Technology
In a satellite network, due to the relative movement between satellites in different orbits or different layers, the intersatellite link changes dynamically.
Huilin Ren, Bingli Guo, Yu Zhou, Luozhang Liang, Hai Yang, Kuan Yan, Shanguo Huang   +6 more
doaj   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Diffusion Basis Spectrum Imaging of Tissue Microstructure and Early Treatment in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Conventional MRI cannot resolve the coexisting pathological processes within multiple sclerosis tissue. Diffusion Basis Spectrum Imaging decomposes the diffusion signal into fiber, cell, and hindered ratios indexing axonal integrity, cellularity, and extracellular space, respectively.
Apisit Kaewsanit, Aime Luna, Bradley Judge, Nicole Shelley, Karl Friedrichsen, Jayashree Rajamanickam, Zhude Tu, Yong Wang, Tammie L. S. Benzinger, Qing Wang, Matthew R. Brier   +10 more
wiley   +1 more source

Preventive start‐time optimisation of open shortest path first link weights for hose model

IET Networks, 2014
Optimising link weights in an open shortest path first network is a challenging traffic engineering problem to reduce network congestion. Most of the previous studies have focused on the application of start‐time optimisation (SO) and run‐time optimisation on both pipe and hose models of link weight optimisation.
R. Sandaruwan Ranaweera, Mohammad Kamrul Islam, Eiji Oki   +2 more
openaire   +2 more sources

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

Urban Vehicle Route Choice Modeling Based on Multi-Source Trajectory Data and Adversarial Inverse Reinforcement Learning

Applied Sciences
To address the limitations of traditional route choice models, including their dependence on manually constructed path sets, their difficulty in capturing nonlinear decision preferences, and their insufficient consideration of dynamic congestion factors,
Shukang Zheng, Changjiang Zheng, Genhua Ma, Xinyi Xie, Ye Lu, Boxuan Wu   +5 more
doaj   +1 more source

Optimasi Jaringan Routing Open Shortest Path First Dengan Menggunakan Multiprotocol Label Switching

Briliant: Jurnal Riset dan Konseptual, 2020
Routing adalah sebuah proses dimana item dapat disampaikan melalui sebuah rute jaringan yang terkonfigurasi untuk mencapai titik tujuan dari suatu lokasi. Universitas Merdeka Malang masih menggunakan static routing dalam jaringan yang berskala bersekala besar.
Ronald David Marcus, Rahmad Anjar Saputro, Fandi Yulian Pamuji   +2 more
openaire   +1 more source

Artificial Intelligence–Based Online Symptom Assessment Tools for Systemic Lupus Erythematosus Diagnosis: Patient Perspectives

Arthritis Care &Research, EarlyView.
Objective The objective of this article is to identify perceptions of patients with systemic lupus erythematosus (SLE) regarding artificial intelligence (AI)–based online symptom assessment tools, and the potential of these tools to address diagnostic barriers.
Olivia A. Stein, Jennifer L. F. Lee, Evelyne Vinet, Arielle Mendel, Christian A. Pineau, Fares Kalache, Louis‐Pierre Grenier, Sasha Bernatsky   +7 more
wiley   +1 more source