Results 51 to 60 of about 1,565,431 (306)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Patents and The Regress of Useful Arts [PDF]
, 2009 Patent systems are often justified by an assumption that innovation will be spurred by the prospect of patent protection, leading to the accrual of greater societal benefits than would be possible under non-patent systems.
Tomlinson, Bill, Torrance, Andrew W.
core +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Affiliated Participation in Open Source Communities [PDF]
, 2019 Background: The adoption of Free/Libre and Open Source Software (FOSS) by institutions is significantly increasing, and so is the affiliated participation (the participation of industry engineers in open source communities as part of their jobs).
Alami, Adam, Wasowski, Andrzej
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
, 2017 Organizations embark on open innovation initiatives to sweep in external knowledge, practices and resources in cooperation with partners. This contrasts to the mainstream private innovation approach of in-house research and development sponsored solely by an incorporated funder, with intellectual property protected by copyright.
openaire +2 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Journal of Theoretical and Applied Electronic Commerce ResearchOpen-source generative AI technologies offer transparent and customizable alternatives to proprietary AI systems, the concept of which closely aligns with the principles of open innovation.
Suengjae Hong +3 more
doaj +1 more source
Innovation in neglected tropical disease drug discovery and development
Infectious Diseases of Poverty, 2018 Background Neglected tropical diseases (NTDs) are closely related to poverty and affect over a billion people in developing countries. The unmet treatment needs cause high mortality and disability thereby imposing a huge burden with severe social and ...
Hong-Bo Weng +2 more
doaj +1 more source
Open Source Hardware and Healthcare Collaborative Platforms: 'Common Legal Challenges'
Journal of Open Hardware, 2020 Open collaborative platforms to share open source hardware project designs are a growing paradigm. In the healthcare sector, platforms – such as Careables.org, Patient Innovation, Makers Making Change – are becoming a popular means to share knowledge and
Elisabetta Biasin, Erik Kamenjašević
doaj +1 more source