Results 71 to 80 of about 1,658,706 (311)

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Roxbury Township's Open Space and Recreation Plan

open access: yes, 1999
This Open Space and Recreation Plan provides guidelines for identifying specific properties that will preserve the environment of Roxbury Township and supplement existing recreation areas.

core   +1 more source

A universal framework for Space Resource Utilisation (SRU) [PDF]

open access: yes, 2019
Space Resource Utilisation (SRU) or In Situ Resource Utilisation (ISRU) is the use of natural resources from the Moon, Mars and other bodies for use in situ or elsewhere in the Solar System.
Meurisse, A   +19 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Reclaiming open space for the young: An intergenerational perspective on design

open access: yes, 2004
http://www.openspace.eca.ac.uk/conference/proceedings/summary/Haider ...
Kaplan, Matthew, Haider, Jawaid
core  

Walking accessibility to neighbourhood open space in a multi-level urban environment of Hong Kong

open access: yes, 2020
This study presents the spatial analysis of walking accessibility to a public facility in a hilly, multi-level urban environment. Our spatial database includes street topography, physical impedances, formal crossings, and designated access points in ...
Wong, KKH, Tang, KSS, Wong, SW, Tang, BS
core   +1 more source

A framework for assessing grey multitasking effectiveness of satellite communication constellation

open access: yesScientific Reports
Task effectiveness, defined as the likelihood that a system will complete specific tasks under predefined conditions and within a given timeframe, is a crucial indicator of the system’s overall performance and fundamental quality attributes.
Ruirui Shao   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

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