Results 141 to 150 of about 134,869 (325)

A multicolour CCD photometric and mass function study of the distant southern open star clusters NGC 3105, NGC 3603, Melotte 105, Hogg 15, NGC 4815, Pismis 20 and NGC 6253

open access: yes, 2001
We derive cluster parameters and mass functions from new UBVRI CCD photometric observations of ~3500 stars reaching down to V ~20mag for the distant southern open star clusters NGC 3105, NGC 3603, Melotte 105, Hogg 15, NGC 4815, Pismis 20 and NGC 6253 ...
R. Sagar, U. Munari, K. S. Boer
semanticscholar   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

open access: yesMolecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka   +10 more
wiley   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

Massive Clusters and OB Associations as Output of Massive Star Formation in Gaia Era

open access: yesUniverse
Over the past two decades, our understanding of star formation has undergone a major shift, driven by a wealth of data from infrared, submillimeter and radio surveys. The emerging view depicts star formation as a hierarchical process, which predominantly
Ignacio Negueruela
doaj   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Young Star Clusters Dominate the Production of Detached Black Hole–Star Binaries

open access: yesThe Astrophysical Journal
The recent discovery of two detached black hole–star (BH–star) binaries from Gaia’s third data release has sparked interest in understanding the formation mechanisms of these systems.
Ugo Niccolò Di Carlo   +3 more
doaj   +1 more source

The CFHT Open Star Cluster Survey. II. Deep CCD Photometry of the Old Open Star Cluster NGC 6819 [PDF]

open access: bronze, 2001
Jasonjot Singh Kalirai   +8 more
openalex   +1 more source

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