Results 121 to 130 of about 16,650,235 (304)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The age distribution of galactic open clusters

, 1991
The fifth edition of the Lynga 'Catalogue of open cluster data' (1987) is used to obtain a number-complete sample of galactic open clusters, which represents a suitable data base to deduce information on the evolution of the system of open clusters in ...
P. Battinelli, CAPUZZO DOLCETTA, Roberto Angelo   +1 more
core  

Global survey of star clusters in the Milky Way: III. 139 new open clusters at high Galactic latitudes [PDF]

, 2014
Context. An earlier analysis of the Milky Way Star Cluster (MWSC) catalogue revealed an apparent lack of old (t â?¤ 1 Gyr) open clusters in the solar neighbourhood (d â?¥ 1 kpc). Aims.
Kharchenko, N.V., S. Schmeja, S. Röser, N. V. Kharchenko, E. Schilbach, Schmeja, S., A. E. Piskunov, R.-D. Scholz, Piskunov, A.E., D. Froebrich, Roser, S., Schilbach, E., Froebrich, Dirk, Scholz, R.D.   +13 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Evidence Against Primordial Mass Segregation in Young Open Clusters: A Bayesian Multiscale Analysis of 3881 Gaia DR3 Clusters

The Astronomical Journal
The origin of mass segregation in open clusters—whether it is primordial (imprinted at birth) or dynamical (evolved over time)—remains a subject of intense debate. We present a comprehensive multi-scale analysis of 3881 open clusters using high-precision
Su Zhang
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

The Secret Lives of Open Clusters: a Multiwavelength Examination of Three Open Clusters

Star clusters are well known for their dynamical interactions, an outcome of their high stellar densities; in this paper we use multiwavelength observations to search for the unique outcomes of these interactions in three nearby Galactic open clusters ...
Hurley, Jarrod, Dage, Kristen C., van Loon, Jacco Th., Sudha, Malu, Anderson-Baldwin, Jasmine, Rao, Khushboo K., Hunt, Emily L., Patil, Aarya, Willingham, Jayde, Mathieu, Robert D., Hopkins, Andrew M., Oh, Kwangmin, Plotkin, Richard M., Tremou, Evangelia   +13 more
core   +1 more source

Lost Sisters Found: TESS and Gaia Reveal a Dissolving Pleiades Complex

The Astrophysical Journal
Most star clusters dissolve into the Galaxy over tens to hundreds of millions of years after they form. While recent Gaia studies have honed our view of cluster dispersal, the exact chronology of which star formation events begat which star cluster ...
Andrew W. Boyle, Luke G. Bouma, Andrew W. Mann   +2 more
doaj   +1 more source

The spin, expansion, and contraction of open star clusters

Astronomy & Astrophysics
Context. Empirical constraints on the internal dynamics of open clusters are important for understanding their evolution and evaporation. High-precision astrometry from Gaia DR3 is thus useful to observe aspects of the cluster dynamics. Aims. This work aims to identify dynamically peculiar clusters such as spinning and expanding clusters.
Vikrant V. Jadhav, Pavel Kroupa, Wenjie Wu, Jan Pflamm-Altenburg, Ingo Thies   +4 more
openaire   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source