Results 111 to 120 of about 51,682 (265)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Evidence for Dynamical Filtering: High Binary Fraction, Hard-binary Excess, and Unresolved Triples in the Surviving Core of NGC 6791

The Astrophysical Journal
We present a deep photometric analysis of the main-sequence (MS) population in the old, metal-rich open cluster (OC) NGC 6791 using Gaia Data Release 3 data.
Huanbin Chi, Zhi Li, Feng Wang, Xuefen Tian, Linfeng Chang, Hongbo Liu, Yiqin Liu   +6 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

PHR J1724-3859: A Bipolar Planetary Nebula in Open Cluster Trumpler 25

The Astrophysical Journal
Planetary nebulae (PNs) studies are essential for understanding the late stellar evolution of low-to-intermediate mass stars. PNs in open clusters (OC) are rare but valuable since their study directly links their properties to those of their progenitors,
Vasiliki Fragkou, Quentin A. Parker, Denise R. Gonçalves   +2 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Probing the Nature of Rotation in the Pleiades, Alpha Persei, and Hyades Clusters

The Astrophysical Journal
Unraveling the internal kinematics of open clusters is crucial for understanding their formation and evolution. However, there is a dearth of research on this topic, primarily due to the lack of high-quality kinematic data.
C. J. Hao, Y. Xu, L. G. Hou, S. B. Bian, Z. H. Lin, Y. J. Li, Y. W. Dong, D. J. Liu   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Double Compact Binary Merger Rate Density in Open Star Clusters: Black Holes, Neutron Stars, and White Dwarfs

The Astrophysical Journal
Studying compact object binary mergers in star clusters is crucial for understanding stellar evolution and dynamical interactions in galaxies. Open clusters in particular are more abundant over cosmic time than globular clusters.
Savannah Cary, Michiko Fujii, Long Wang, Ataru Tanikawa   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Quantifying the Limits of TESS Stellar Rotation Measurements with the K2-TESS Overlap

The Astrophysical Journal
The Transiting Exoplanet Survey Satellite (TESS) has provided stellar rotation periods across much of the sky through high-precision light curves, but the reliability and completeness of these measurements require careful evaluation.
Andrew W. Boyle, Andrew W. Mann, Jonathan Bush   +2 more
doaj   +1 more source