Results 91 to 100 of about 51,682 (265)
The Deeper Studies of IC 2488 and IC 2714
The Astrophysical JournalIn this paper, we use two methods, an algorithm of the density-based spatial clustering of applications with noise combined with the Gaussian mixture model, and the maximum likelihood method, to study two open clusters: IC 2488 and IC 2714 with Gaia Data
Jin-Sheng Qiu +4 more
doaj +1 more source
FIRST, SECOND, AND THIRD MASSIVE STARS IN OPEN CLUSTERS [PDF]
The Astrophysical Journal, 2011 The goal of this paper is to study possibilities of using first, second and third massive stars in open clusters to estimate total cluster mass and membership. We built estimator functions with the use of numerical simulations and analytical approximations and studied the precision and error distribution of the obtained estimator functions.
openaire +3 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Multiple Machine Learning as a Powerful Tool for Star Cluster Analysis
The Astronomical JournalThis work proposes a multiple machine learning method (MMLM) aiming to improve the accuracy and robustness of the analysis of star clusters. The MMLM performance is evaluated by applying it to the reanalysis of an old binary cluster candidate—comprised ...
Denilso Camargo
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Disk-locking Regulates Stellar Rotation in Young Clusters: Insights from NGC 2264
The Astrophysical JournalMany young clusters possess extended main sequences, a phenomenon commonly ascribed to stellar rotation. However, the mechanism behind their very wide stellar rotation distributions remains unclear.
Yutian Bu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
The Astrophysical JournalStars in an open cluster are assumed to have formed from a broadly homogeneous distribution of gas, implying that they should be chemically homogeneous.
Amaya Sinha +6 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source