Results 81 to 90 of about 58,178 (265)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Forest Fire Clustering: A Novel Tool for Identifying Star Members of Clusters
The Astronomical JournalIn the era of a data-driven landscape, the development of an efficient and interpretable method has become a pivotal tool for robustly identifying memberships of clusters.
Xingyin Wei +8 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Utilizing Voronoi Tessellations to Determine Radial Density Profiles
The Astronomical JournalWe have developed a novel method of determining 2D radial density profiles for astronomical systems of discrete objects using Voronoi tessellations. This Voronoi-based method was tested against the standard annulus-based method on five simulated systems ...
Veronika Dornan, William E. Harris
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Emergence of a Lithium Dip in ∼35 Myr “Snake” Open Clusters
The Astrophysical Journal LettersWe report the discovery of a lithium dip (Li dip) in the stellar “Snake” (age = 35 ± 5 Myr), challenging the classical view that Li dips emerge only at ages ≳150 Myr.
Yun-Yi Zhang +4 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The Deeper Studies of IC 2488 and IC 2714
The Astrophysical JournalIn this paper, we use two methods, an algorithm of the density-based spatial clustering of applications with noise combined with the Gaussian mixture model, and the maximum likelihood method, to study two open clusters: IC 2488 and IC 2714 with Gaia Data
Jin-Sheng Qiu +4 more
doaj +1 more source
FIRST, SECOND, AND THIRD MASSIVE STARS IN OPEN CLUSTERS [PDF]
The Astrophysical Journal, 2011 The goal of this paper is to study possibilities of using first, second and third massive stars in open clusters to estimate total cluster mass and membership. We built estimator functions with the use of numerical simulations and analytical approximations and studied the precision and error distribution of the obtained estimator functions.
openaire +3 more sources