Results 101 to 110 of about 51,682 (265)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Evidence Against Primordial Mass Segregation in Young Open Clusters: A Bayesian Multiscale Analysis of 3881 Gaia DR3 Clusters

The Astronomical Journal
The origin of mass segregation in open clusters—whether it is primordial (imprinted at birth) or dynamical (evolved over time)—remains a subject of intense debate. We present a comprehensive multi-scale analysis of 3881 open clusters using high-precision
Su Zhang
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Lost Sisters Found: TESS and Gaia Reveal a Dissolving Pleiades Complex

The Astrophysical Journal
Most star clusters dissolve into the Galaxy over tens to hundreds of millions of years after they form. While recent Gaia studies have honed our view of cluster dispersal, the exact chronology of which star formation events begat which star cluster ...
Andrew W. Boyle, Luke G. Bouma, Andrew W. Mann   +2 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Velocity Dispersion of the Open Cluster NGC 2571 by Radial Velocities and Proper Motions

The Astronomical Journal
We use a kernel density estimator method to evaluate the stellar velocity dispersion in the open cluster NGC 2571. We derive the 3D velocity dispersion using both proper motions as extracted from Gaia Data Release 3 and single-epoch radial velocities as ...
Maxim V. Kulesh, Aleksandra E. Samirkhanova, Giovanni Carraro, Joao V. Sales-Silva, Roberto Capuzzo Dolcetta, Anton F. Seleznev   +5 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

The spin, expansion, and contraction of open star clusters

Astronomy & Astrophysics
Context. Empirical constraints on the internal dynamics of open clusters are important for understanding their evolution and evaporation. High-precision astrometry from Gaia DR3 is thus useful to observe aspects of the cluster dynamics. Aims. This work aims to identify dynamically peculiar clusters such as spinning and expanding clusters.
Vikrant V. Jadhav, Pavel Kroupa, Wenjie Wu, Jan Pflamm-Altenburg, Ingo Thies   +4 more
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Li Evolution among Stars of Low/Intermediate Mass: the Metal-deficient Open Cluster NGC 2204

The Astronomical Journal
We have analyzed high-dispersion spectra in the Li 6708 Å region for 167 stars within the anticenter cluster NGC 2204. From 105 probable members, abundance analysis of 45 evolved stars produces [Fe/H] = −0.40 ± 0.12, [Si/Fe] = 0.14 ± 0.12, [Ca/Fe] = 0.29
Barbara J. Anthony-Twarog, Constantine P. Deliyannis, Aaron Steinhauer, Qinghui Sun, Bruce A. Twarog   +4 more
doaj   +1 more source