Results 101 to 110 of about 16,650,235 (304)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Utilizing Voronoi Tessellations to Determine Radial Density Profiles
The Astronomical JournalWe have developed a novel method of determining 2D radial density profiles for astronomical systems of discrete objects using Voronoi tessellations. This Voronoi-based method was tested against the standard annulus-based method on five simulated systems ...
Veronika Dornan, William E. Harris
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Open Innovation Clusters: The Case of Cova da Beira Region (Portugal) [PDF]
This paper aims to reveal the role played by open innovation schemes in the development of new competitive advantages. Furthermore, it aims to present a normative model for networking knowledge clusters, that is, traditional clusters that are applied to ...
Leitão, João
core
Two-dimensional hydrodynamic models of super star clusters with a positive star formation feedback [PDF]
, 2008 Using the hydrodynamic code ZEUS, we perform 2D simulations to determine the fate of the gas ejected by massive stars within super star clusters. It turns out that the outcome depends mainly on the mass and radius of the cluster.
GUILLERMO TENORIO TAGLE, SERGIY SILICH
core
Emergence of a Lithium Dip in ∼35 Myr “Snake” Open Clusters
The Astrophysical Journal LettersWe report the discovery of a lithium dip (Li dip) in the stellar “Snake” (age = 35 ± 5 Myr), challenging the classical view that Li dips emerge only at ages ≳150 Myr.
Yun-Yi Zhang +4 more
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
, 2012 poster"Ecology of star clusters" examines the interactions of stars, and what can be gleaned from those interactions about the evolution and ultimate fate of star clusters large and small.
Lehman, Fred +2 more
core
The Deeper Studies of IC 2488 and IC 2714
The Astrophysical JournalIn this paper, we use two methods, an algorithm of the density-based spatial clustering of applications with noise combined with the Gaussian mixture model, and the maximum likelihood method, to study two open clusters: IC 2488 and IC 2714 with Gaia Data
Jin-Sheng Qiu +4 more
doaj +1 more source