Results 101 to 110 of about 58,178 (265)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Lost Sisters Found: TESS and Gaia Reveal a Dissolving Pleiades Complex

The Astrophysical Journal
Most star clusters dissolve into the Galaxy over tens to hundreds of millions of years after they form. While recent Gaia studies have honed our view of cluster dispersal, the exact chronology of which star formation events begat which star cluster ...
Andrew W. Boyle, Luke G. Bouma, Andrew W. Mann   +2 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Velocity Dispersion of the Open Cluster NGC 2571 by Radial Velocities and Proper Motions

The Astronomical Journal
We use a kernel density estimator method to evaluate the stellar velocity dispersion in the open cluster NGC 2571. We derive the 3D velocity dispersion using both proper motions as extracted from Gaia Data Release 3 and single-epoch radial velocities as ...
Maxim V. Kulesh, Aleksandra E. Samirkhanova, Giovanni Carraro, Joao V. Sales-Silva, Roberto Capuzzo Dolcetta, Anton F. Seleznev   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The spin, expansion, and contraction of open star clusters

Astronomy & Astrophysics
Context. Empirical constraints on the internal dynamics of open clusters are important for understanding their evolution and evaporation. High-precision astrometry from Gaia DR3 is thus useful to observe aspects of the cluster dynamics. Aims. This work aims to identify dynamically peculiar clusters such as spinning and expanding clusters.
Vikrant V. Jadhav, Pavel Kroupa, Wenjie Wu, Jan Pflamm-Altenburg, Ingo Thies   +4 more
openaire   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Li Evolution among Stars of Low/Intermediate Mass: the Metal-deficient Open Cluster NGC 2204

The Astronomical Journal
We have analyzed high-dispersion spectra in the Li 6708 Å region for 167 stars within the anticenter cluster NGC 2204. From 105 probable members, abundance analysis of 45 evolved stars produces [Fe/H] = −0.40 ± 0.12, [Si/Fe] = 0.14 ± 0.12, [Ca/Fe] = 0.29
Barbara J. Anthony-Twarog, Constantine P. Deliyannis, Aaron Steinhauer, Qinghui Sun, Bruce A. Twarog   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Kinematic Signatures of a Binary-rich Population in the Pleiades

The Astrophysical Journal
Binary stars can influence the dynamical evolution of open clusters by acting as internal energy sources. Using Gaia DR3 astrometry together with the Pleiades binary catalog of Liu et al., we investigate the projected internal kinematics of single stars ...
Huanbin Chi, Feng Wang
doaj   +1 more source