Results 101 to 110 of about 27,793,750 (279)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

1998 General Assembly Legislation Related to Water

, 1998
The Virginia General Assembly held its regular session from January 14 to March 17, then reconvened April 22-23 to respond to the governor’s vetoes.
Manfre, Joseph, Virginia Water Resources Research Center   +1 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Development of a standard series for pump-jet propulsors and data-driven regression for performance prediction

International Journal of Naval Architecture and Ocean Engineering
Pump-jet propulsors are widely used in marine applications because of their advantages in propulsive efficiency, cavitation performance, and low noise performance.
Jinghan Su, Youjiang Wang, Fang Li, Li Zhou   +3 more
doaj   +1 more source

Water-mediated cation intercalation of open-framework indium hexacyanoferrate with high voltage and fast kinetics

Nature Communications, 2016
Rechargeable aqueous metal-ion batteries are promising for large-scale applications, but performance and stability issues still remain. Here the authors utilize open-framework indium hexacyanoferrate cathodes to improve performance, showing that water ...
Liang Chen, Hezhu Shao, Xufeng Zhou, Guoqiang Liu, Jun Jiang, Zhaoping Liu   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Bow Optimization of a Polar Vessel Based on Resistance Approximation Model

Applied Sciences
Excellent resistance performance constitutes a longstanding objective in ship design and serves as a primary means of reducing operational costs. Polar transport vessels operate along trade routes that traverse both open water and ice-covered regions ...
Zhipeng Wang, Zhailiu Hao, Naxin Wei
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Towards Continuous Swim Leg Analytics in Olympic Triathlon: A Systematic Review of Sensor-Based Assessment Approaches in Open-Water Sports Contexts

Sensors
Global Navigation Satellite Systems (GNSS) offer precise movement analyses based on distance and speed in open-water sports. Despite the influence of swimming in triathlon, its performance analysis remains underdeveloped due to methodological limitations
Jannik Seelhöfer, Jürgen Wick, Maren Witt   +2 more
doaj   +1 more source

Swimming Performance in Elite Triathletes: Comparison Between Open Water and Pool Conditions

Scandinavian Journal of Medicine & Science in Sports
ABSTRACTThis study aimed to compare performance, kinematic, and physiological variables between open water and pool swimming conditions in elite triathletes and to examine the associations between conditions on these variables. Fourteen elite triathletes (10 males and 4 females [23.4 ± 3.8 years]) performed two 1500‐m swimming tests in open water and ...
Óscar López‐Belmonte, Jesús J. Ruiz‐Navarro, Ana Gay, Francisco Cuenca‐Fernández, Raúl Arellano, Roberto Cejuela   +5 more
openaire   +4 more sources