Results 51 to 60 of about 27,770,463 (280)

Comparison Study of the k − k_L − ω and γ − Re_θ Transition Model in the Open-Water Performance Prediction of a Rim-Driven Thruster

International Journal of Turbomachinery, Propulsion and Power
The present work examines the capabilities of two transition models implemented in ANSYS Fluent in the open-water performance prediction of a rim-driven thruster (RDT).
Bao Liu, Maarten Vanierschot, Frank Buysschaert   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Experimental datasets of surface piercing propellers operating in open-water conditions

International Journal of Naval Architecture and Ocean Engineering
The present experimental datasets provide the open-water performance characteristics of surface-piercing propellers under various operating conditions.
Jeongsoo Ha, Jaeheon Kim, Shin Hyung Rhee   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

A Numerical Approach to Evaluate the Geothermal Potential of a Flooded Open-Pit Mine: Example from the Carey Canadian Mine (Canada)

Energies
Abandoned mines represent an innovative and under-exploited resource to meet current energy challenges, particularly because of their geothermal potential.
Samuel Lacombe, Félix-Antoine Comeau, Jasmin Raymond   +2 more
doaj   +1 more source

Lactate Threshold and Swimming Performance in World-Class Open-Water Swimmers

International Journal of Sports Physiology and Performance
Purpose: The assessment of lactate threshold (LT) and its relationship to open-water (OW) performance is crucial. This study aimed (1) to analyze LT in world-class OW swimmers, (2) to compare swimming speed at LT (SSLT) and 4 mmol·L−1 of blood lactate concentration ([La−]; SS4), and (3) to examine the relationships between SSLT and swimming performance.
Óscar López-Belmonte, Roberto Baldassarre, Jesús J. Ruiz-Navarro, Marco Bonifazi, Raúl Arellano, Maria Francesca Piacentini   +5 more
openaire   +4 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source