Results 81 to 90 of about 57,420 (278)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Frontiers in Behavioral Neuroscience, 2017 The pond snail Lymnaea stagnalis learns and forms long-term memory (LTM) following both operant conditioning of aerial respiratory behavior and classical conditioning of taste aversive behavior.
Hiroshi Sunada +9 more
doaj +1 more source
Learning obstacle avoidance with an operant behavioral model [PDF]
, 2004 Artificial intelligence researchers have been attracted by the idea of having robots learn how to accomplish a task, rather than being told explicitly.
Gutnisky, D. A. +1 more
core +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Adverse Aftereffects of Methotrexate as Chemotherapy on Cognitive Deficits in Rat Models [PDF]
, 2020 Patients with acute lymphoblastic leukemia have a high five-year survival rate thanks to methotrexate (MTX). However, cognitive side effects are reported, characterized as chemo brain.
Kang, Jubin
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Learning in Plants: Lessons from Mimosa pudica
Frontiers in Psychology, 2016 This article provides an overview of the early Mimosa pudica literature; much of which is in journals not easily accessible to the reader. In contrast to the contemporary plant learning literature which is conducted primarily by plant biologists, this ...
Charles Ira Abramson +1 more
doaj +1 more source
Writing a Children Story Book: Rosaline the Beautiful Rose [PDF]
, 2016 This project brings up an issue about beauty concept in a form of children's story book with fantasy genre for children at the ages of 12 to 15. The story shows some beauty concepts in the world through the main character's fantastical adventure.
Irawan, S. (Stefanny) +1 more
core
Dorsal-CA1 hippocampal neuronal ensembles encode nicotine-reward contextual associations [PDF]
, 2017 Natural and drug rewards increase the motivational valence of stimuli in the environment that, through Pavlovian learning mechanisms, become conditioned stimuli that directly motivate behavior in the absence of the original unconditioned stimulus.
Bruchas, Michael R +4 more
core +3 more sources