Results 91 to 100 of about 801,725 (306)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

MODELING OPERATING RATE DECISIONS IN THE CANADIAN FOREST INDUSTRIES [PDF]

This article examines the problem of characterizing production structures when there is input fixity but fixed inputs can be utilized with varying intensities.
Constantino, Luis, Townsend, Gary
core   +1 more source

The manned maneuvering unit flight controller arm [PDF]

, 1983
The Manned Maneuvering Unit (MMU) and its support equipment provide an extravehicular astronaut mobility, and the ability to work outside the confines of the Shuttle Orbiter payload bay.
Falkner, K. E.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Predicting Operating Income via a Generalized Operating-Leverage Model

International Journal of Financial Studies
We propose a generalized, practitioner-oriented operating-leverage model for predicting operating income using net sales, cost of sales, depreciation, and SG&A.
Sherwood Lane Lambert, Kevin Krieger, Nathan Mauck   +2 more
doaj   +1 more source

Study of Supervisory Control Implementation in A Small Scale Variable Speed Wind Turbine

E3S Web of Conferences, 2018
In relation to improve wind energy production, efforts to increase the extraction of wind energy should be done when there is a decrease in wind power. The decline occurs when there is a change in wind speed. At low wind speed operating range, such as in
Indriawati Katherin, Musyafa Ali, Widjiantoro Bambang L., Milatul Ummah Anna   +3 more
doaj   +1 more source

Chance-Constrained Equilibrium in Electricity Markets With Asymmetric Forecasts

, 2020
We develop a stochastic equilibrium model for an electricity market with asymmetric renewable energy forecasts. In our setting, market participants optimize their profits using public information about a conditional expectation of energy production but ...
Dvorkin, Vladimir, Kazempour, Jalal, Pinson, Pierre   +2 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Financial stability strategies: Bankruptcy courts and corporate capital structure adjustment

International Review of Economics & Finance
This paper examines the effects of bankruptcy courts on the adjustment of corporate capital structures among A-share listed companies from 2010 to 2022, utilizing a multi-timepoint difference-in-differences model.
Yang Cui, Yanliang Zhang
doaj   +1 more source

FDI, Foreign Affiliate Operations, and the Transfer Process: Macroeconomic Adjustment to FDI Inflows in the Case of Costa Rica [PDF]

The theoretical and empirical literature on the macroeconomic effects of capital inflows posits that a net inflow of foreign capital leads to an equilibrium real exchange rate (RER) appreciation through an expansion in aggregate demand.
Rodrigo Cubero-Brealey
core