Results 81 to 90 of about 1,270,350 (303)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Thermodynamic Analysis of Simple Gas Turbine Cycle with Multiple Regression Modelling and Optimization [PDF]

Mehran University Research Journal of Engineering and Technology, 2014
In this study, thermodynamic and statistical analyses were performed on a gas turbine system, to assess the impact of some important operating parameters like CIT (Compressor Inlet Temperature), PR (Pressure Ratio) and TIT (Turbine Inlet Temperature) on ...
Abdul Ghafoor Memon, Rizwan Ahmed Memon, Khanji Harijan   +2 more
doaj  

Determination of compressor in-stall characteristics from engine surge transients [PDF]

A technique for extracting the in-stall pumping characteristics for an axial flow compressor operating in an engine system environment is developed. The technique utilizes a Hybrid computer simulation of the compressor momentum equation into which actual
Chiaramonte, F. P., Lorenzo, C. F., Mehalic, C. M.   +2 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Optimal Coordination of Directional Overcurrent Relays Using an Exponential-Based Non-Standard Characteristic and the Nutcracker Optimizer

Gazi Üniversitesi Fen Bilimleri Dergisi
Directional overcurrent relays (DOCRs) play a crucial role in protecting sub-transmission and distribution systems due to their simplicity and cost- ffectiveness. For selective and rapid protection, proper coordination of these relays is essential.
Alişan Ayvaz
doaj   +1 more source

Solutions of some problems in applied mathematics using MACSYMA [PDF]

Various Symbolic Manipulation Programs (SMP) were tested to check the functioning of their commands and suitability under various operating systems. Support systems for SMP were found to be relatively better than the one for MACSYMA.
Lam, Maria, Punjabi, Alkesh
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A Miniaturized Dual-Mode Bandpass Filter Using Slot Spurline Technique

International Journal of Antennas and Propagation, 2013
A miniaturized dual-mode bandpass filter (BPF) with elliptic function response using slot spurline is designed in this paper. The slot spurline can not only splits the degenerate modes but also determine the type of filter characteristic (Chebyshev or ...
Haiwen Liu, Jiuhuai Lei, Jing Wan, Yan Wang, Feng Yang, Suping Peng   +5 more
doaj   +1 more source

Doppler‐Derived Renal Venous Stasis Index in the Prognosis of Right Heart Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Persistent congestion with deteriorating renal function is an important cause of adverse outcomes in heart failure. We aimed to characterize new approaches to evaluate renal congestion using Doppler ultrasonography.
Faeq Husain‐Syed, Horst‐Walter Birk, Claudio Ronco, Tanja Schörmann, Khodr Tello, Manuel J. Richter, Jochen Wilhelm, Natascha Sommer, Ewout Steyerberg, Pascal Bauer, Hans‐Dieter Walmrath, Werner Seeger, Peter A. McCullough, Henning Gall, H. Ardeschir Ghofrani   +14 more
doaj   +1 more source