Results 91 to 100 of about 2,782,243 (307)
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Shiyou jixie, 2018 In highly deviated wells, increased WOB would increase the bending deformation and vibration of the drill string, leading to well inclination, well drift, twist-off of the drill string and premature bit wear.
Fu Chuanhong +2 more
doaj
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Defrosting Characteristics of Refrigeration, Heating, and Hot Water Combined Air-conditioning System
Zhileng xuebao, 2020 Frost on the surface of an outdoor heat exchanger will seriously affect the operating performance and safety factor of a refrigeration-, heating-, and hot-water combined air-conditioning system when it is operating in winter.
Pei Xiangxiang +5 more
doaj
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A Flexible Mathematical Model for Dissimilar Operating Modes of a Switched Reluctance Machine
IEEE Access, 2018 Switched reluctance motor (SRM) is an energy efficient machine, which receives electrical energy from the power source and returns part of the stored magnetic energy back to the supply, during each cycle of the machine operation.
Ali Asghar Memon +5 more
doaj +1 more source
Information System Adoption and Use in Local Cooperatives [PDF]
Advances in information technology can help local cooperatives remain competitive in a changing agricultural sector. This study examines the adoption and use of information systems by local farm supply and grain cooperatives and the relationships between
King, Robert P., Shuker, Iain G.
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Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Free-flight wind-tunnel investigation of a four-engine sweptwing upper-surface blown transport configuration [PDF]
The dynamic stability and control characteristics of a four-engine turbofan transport model having an upper-surface blown jet flap were investigated by means of the free-flight technique in the Langley full-scale tunnel. The flight characteristics of the
Parlett, L. P.
core +1 more source